Accuracy of Frozen Sections for Intraoperative Diagnosis of Complex Atypical Endometrial Hyperplasia

Turan, Taner; Karadag, Burak; Karabuk, Emine; Tulunay, Gokhan; Ozgul, Nejat; Gultekin, Murat; Boran, Nurettin; Isikdogan, Zuhal; Kose, Mehmet Faruk

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자료유형: 학술저널

저자정보: Turan, Taner (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) Karadag, Burak (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) Karabuk, Emine (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) Tulunay, Gokhan (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) Ozgul, Nejat (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) Gultekin, Murat (Cancer Control Department, Turkish Ministry of Health) Boran, Nurettin (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital) Isikdogan, Zuhal (Pathology Division Etlik Zubeyde Hanim Women's Health Research and Teaching Hospital) Kose, Mehmet Faruk (Gynecologic Oncology Division, Zubeyde Hanim Women's Health Research and Teaching Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제5호

발행연도: 2012.1

수록면: 1,953 - 1,956 (4page)

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Objective: The purpose of this study was to correlate the histological diagnosis made during intraoperative frozen section (FS) examination of hysterectomy samples with complex atypical endometrial hyperplasia (CAEH) diagnosed with definitive paraffin block histology. Methods: FS pathology results of 125 patients with a preoperative biopsy showing CAEH were compared retrospectively with paraffin block pathology findings. Results: Paraffin block results were consistent with FS in 78 of 125 patients (62.4%). The FS sensitivity and specificity of detecting cancer were 81.1% and 97.9%, with negative and positive predictive values of 76.7%, and 98.4%, respectively. Paraffin block results were reported as endometrial cancer in 77 of 125 (61.6%) patients. Final pathology was endometrial cancer in 45.3% patients diagnosed at our center and 76.9% for patients who had their diagnosis at other clinics (p=0.018). Paraffin block results were consistent with FS in 62.4% of all cases Consistence was 98.4% in patients who had endometrial cancer in FS. Conclusion: FS does not exclude the possibility of endometrial cancer in patients with the preoperative diagnosis of CAEH. In addition, sufficient endometrial sampling is important for an accurate diagnosis.

#Complex atypical endometrial hyperplasia #endometrial cancer #frozen section

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Turan, Taner

소속기관 Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women’s Health Education and Research Hospit