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논문 기본 정보

자료유형
학술저널
저자정보
Dong, Wei (Institute of Oncology, Provincial Hospital affiliated to Shandong University, Shandong University) Meng, Long (Department of Thoracic Surgery, Provincial Hospital affiliated to Shandong University, Shandong University) Shen, Hong-Chang (Institute of Oncology, Provincial Hospital affiliated to Shandong University, Shandong University) Du, Jia-Jun (Institute of Oncology, Provincial Hospital affiliated to Shandong University, Shandong University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제5호
발행연도
2012.1
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2,021 - 2,023 (3page)

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Purpose: DBC2 (Deleted in Breast Cancer 2) has been indicated to be a tumor suppressor gene in many cancers including lung adenocarcinoma recently. In this study, we aimed to explore the expression status of DBC2 in different subtypes of lung adenocarcinoma (from pre-invasive to invasive lesions), and to determine if downregulation becomes more marked with pathological progression. Methods: We collected 172 tissue samples from different subtypes of lung adenocarcinoma and investigated the frequency of DBC2 loss by immunohistochemistry. Results: Our results indicated that DBC2 downregulation is a relatively frequent event in lung adenocarcinoma. Moreover, as the adenocarcinoma subtype turns to be more invasive, more downregulation occurred. Conclusion: We conclude that loss of DBC2 expression is an early and progressive event in the pathogenesis of lung adenocarcinoma. Positive DBC2 immunohistochemistry may become an indicator for early stage disease and better prognosis of lung adenocarcinomas.

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