Multicentre Hospital-based Case-control Study of Diffuse Large B-cell Lymphoma in Shanghai, China

Fan, Rong; Zhang, Lu-Yao; Wang, Hong; Yang, Bo; Han, Tao; Zhao, Xiao-Li; Wang, Wei; Wang, Xiao-Qin; Lin, Guo-Wei

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자료유형: 학술저널

저자정보: Fan, Rong (Department of Hematology, Huashan Hospital of Fudan University) Zhang, Lu-Yao (Shanghai Medical College of Fudan University) Wang, Hong (Department of Hematology, The First Affiliated Hospital of Soochow University) Yang, Bo (Fudan-Cinpathogen Clinical & Molecular Research Center) Han, Tao (Fudan-Cinpathogen Clinical & Molecular Research Center) Zhao, Xiao-Li (Department of Hematology, Huashan Hospital of Fudan University) Wang, Wei (Department of Hematology, Huashan Hospital of Fudan University) Wang, Xiao-Qin (Department of Hematology, Huashan Hospital of Fudan University) Lin, Guo-Wei (Department of Hematology, Huashan Hospital of Fudan University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제7호

발행연도: 2012.1

수록면: 3,329 - 3,334 (6page)

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Background: Several potential risk factors have been identified for diffuse large B-cell lymphoma (DLBCL); however, epidemiological studies investigating the association between these risk factors and DLBCL have yielded inconsistent results. Objectives: To investigate potential medical, lifestyle, and environmental risk factors of DLBCL in Shanghai, China through a hospital-based case-control study. Method: One-hundred-and-forty-seven newly diagnosed DLBCL patients and 294 sex- and age-matched controls were recruited from 11 hospitals in Shanghai between 2003 and 2007. A standardized structured questionnaire was used to obtain patient data on demographics, medical history, family history, lifestyle, and environmental exposures. Conditional logistic regression models were used to estimate odds ratios (ORs), with 95% confidence intervals (CIs), for risk associated with each data category. Results: History of tuberculosis (TB) infection and "living on a farm" were positively associated with DLBCL (TB: OR=3.05, 95% CI: 1.19-7.80; farm: OR=1.82, 95% CI: 1.21-2.73). In contrast, taking traditional Chinese medicine was negatively associated with DLBCL (OR=0.36, 95% CI: 0.14-0.89). No significant correlation with DLBCL risk was found for any of the other potential risk factors (p>0.05), including but not limited to hair dyes, alcohol drinking, smoking, and home/workplace renovation within one year. Conclusions: Consistent with results from previous studies in other DLBCL case populations, traditional Chinese medicine appeared to have a direct or indirect protective effect against DLBCL. However, this study also identified a possible predisposition for DLBCL in TB sufferers and farmers.

#Diffuse large B-cell lymphoma #epidemiology #case-control study #risk factors #environment #China

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