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논문 기본 정보

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학술저널
저자정보
Son, Kyeong Min (Division of Pulmonary, Allergy, and Critical Care Medicine, Sacred Heart Hospital, Hallym University College of Medicine) Jang, Seung Hun (Division of Pulmonary, Allergy, and Critical Care Medicine, Sacred Heart Hospital, Hallym University College of Medicine) Kang, Hye Ryun (Division of Pulmonary, Allergy, and Critical Care Medicine, Sacred Heart Hospital, Hallym University College of Medicine) Han, Bo Ram (Division of Pulmonary, Allergy, and Critical Care Medicine, Sacred Heart Hospital, Hallym University College of Medicine) Kim, Joo Hee (Division of Pulmonary, Allergy, and Critical Care Medicine, Sacred Heart Hospital, Hallym University College of Medicine) Kim, Hyun Sung (Division of Pulmonary, Allergy, and Critical Care Medicine, Sacred Heart Hospital, Hallym University College of Medicine) Park, Sung Hoon (Division of Pulmonary, Allergy, and Critical Care Medicine, Sacred Heart Hospital, Hallym University College of Medicine) Hwang, Yong Il (Division of Pulmonary, Allergy, and Critical Care Medicine, Sacred Heart Hospital, Hallym University College of Medicine) Kim, Dong Gyu (Division of Pulm) Jung, Ki Suck
저널정보
대한결핵 및 호흡기학회 Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제67권 제4호
발행연도
2009.1
수록면
311 - 317 (7page)

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Background: The methacholine bronchial provocation test is a useful tool for evaluating asthma in patients with normal or near normal baseline lung function. However, the sensitivity of this test is 82~92% at most. The purpose of this study is to evaluate the clinical usefulness of $FEF_{25-75%}$ in identification of airway hyperresponsiveness in patients with suspected asthmatic symptoms. Methods: One hundred twenty-five patients who experienced cough and wheezing within one week prior to their visiting the clinic were enrolled. Results: Sixty-four subjects showed no significant reduction of $FEV_{1}$ or $FEF_{25-75%}$ on the methacholine bronchial provocation test (Group I). In 24 patients, $FEF_{25-75%}$ fell more than 20% from baseline without a 20% fall of $FEV_{1}$ during methacholine challenge (Group II). All patients who had more than 20% fall of $FEV_{1}$ (n=37) also showed more than 20% of reduction in $FEF_{25-75%}$ (Group III). Baseline $FEV_{1}$/FVC (%) and $FEF_{25-75%}$ (L) were higher in group II than group III (81.51${\pm}$1.56% vs. 75.02${\pm}$1.60%, p<0.001, 3.25${\pm}$0.21 L vs. 2.45${\pm}$0.21 L, p=0.013, respectively). Group II had greater reductions of both $FEV_{1}$ and $FEF_{25-75%}$ than group I at 25 mg/mL of methacholine (p<0.001). The provocative concentration of methacholine causing a 20% fall in $FEF_{25-75%}$ in group II was about three-fold higher than that in group III. Conclusion: A 20% fall of $FEF_{25-75%}$ by methacholine provocation can be more sensitive indicator for detecting a milder form of airway hyperresponsiveness than $FEV_{1}$ criteria.

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