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논문 기본 정보

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학술저널
저자정보
Jo, Kyung-Wook (Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) Hong, Yoonki (Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) Park, Jae Seuk (Department of Internal Medicine, Dankook University College of Medicine) Bae, In-Gyu (Department of Internal Medicine, Gyeongsang National University School of Medicine) Eom, Joong Sik (Division of Infectious Diseases, Department of Internal Medicine, Kandong Sacred Heart Hospital College of Medicine, Hallym University College of Medicine) Lee, Sang-Rok (Department of Internal Medicine, Division of Allergy and Infectious Diseases, Cheongju St. Mary's Hospital) Cho, Oh-Hyun (Department of Internal Medicine, Gyeongsang National University School of Medicine) Choo, Eun Ju (Division of Infectious Diseases, Department of Internal Medicine, Soon Chun Hyang University Bucheon Hospital, Soon Chun Hyang University College of Medicine) Heo, Jung Yeon (Department of Internal Medicine, Armed Forces Capital Hospital) Woo, Jun Hee (Division of Infectious Diseases, Asan M) Shim, Tae Sun
저널정보
대한결핵 및 호흡기학회 Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제75권 제1호
발행연도
2013.1
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18 - 24 (7page)

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Background: We investigated the prevalence of latent tuberculosis infection (LTBI) among the health care workers (HCWs) and analyzed its risk factors in South Korea. Methods: A standard questionnaire regarding the baseline demographics and risk factors for LTBI was given to each participant and tuberculin skin test (TST), QuantiFERON-TB GOLD In-Tube (QFT-GIT) assay, and chest radiography were performed. Results: A total of 493 participants, 152 (30.8%) doctors and 341 (69.2%) nurses were enrolled in eight tertiary referral hospitals. The mean age of the subjects was 30.6 years old, and 383 (77.7%) were female. Of the 152 doctors, 63 (41.4%) and 36 (23.7%) were positive by TST and by QTF-GIT, respectively, and among the 341 nurses, 119 (34.9%) and 49 (14.4%) had positive TST and QFT-GIT results, respectively. Overall, the agreement between the two tests was 0.22 by the chance corrected proportional agreement rate (kappa coefficient) in 493 subjects. Experience of working in tuberculosis (TB)-related departments was significantly associated with positive LTBI test results by QFT-GIT assay, not by TST. In multivariate analysis, only age was independently associated with increased risk of a positive TST result, while age and experience of working in TB-related departments (odds ratio, 2.29; 95% confidence interval, 1.01-5.12) were independently associated with increased risk of a positive QFT-GIT result. Conclusion: A high prevalence of LTBI was found among South Korean HCWs. Considering the association between the experience of working in TB-related departments and high risk of LTBI, QFT-GIT may be a better diagnostic test for LTBI than TST in HCWs.
#Latent Tuberculosis #Health Personnel #Tuberculin Test #Interferon-gamma Release Tests #Republic of Korea

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