Clinical Significance of Quantitative Analysis of Plasma Epstein-Barr Virus DNA in Patients of Xinjiang Uygur Nationality with Hodgkin's Lymphoma

Li, Xun; Yang, Shun-E.; Guo, Yun-Quan; Shen, Ming-Xia; Gu, Li; Gulikezi, Gulikezi; Zhao, Bing; Liu, Wei; Tuerxun, Tuerxun; Bai, Jing-Ping

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저자정보: Li, Xun (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University) Yang, Shun-E. (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University) Guo, Yun-Quan (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University) Shen, Ming-Xia (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University) Gu, Li (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University) Gulikezi, Gulikezi (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University) Zhao, Bing (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University) Liu, Wei (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University) Tuerxun, Tuerxun (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University) Bai, Jing-Ping (Department of Medical Oncology, Affiliated Tumor Hospital, Xinjiang Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제12호

발행연도: 2012.1

수록면: 6,379 - 6,384 (6page)

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Objective: To investigate the relationship between plasma EBV-DNA concentration and clinicopathologic features of Hodgkin's lymphoma cases. Methods: At first, the positive rate of plasma EBV-DNA was determined with a nested-PCR method using 45 specimens from Uygur HL patients, as well as 110 healthy people sampled as normal controls. Secondly, using fluorescent quantitative nested-PCR, EBV viral load was assessed in the EBV-DNA positive plasma samples. Then, relationships between plasma EBV viral load and clinicopathologic features of HL patients were analyzed. Results: The positive rate of plasma EBV-DNA of HL patients was significantly higher than that of normal controls (53.3% vs 26.4%, P=0.001). There was no significant difference about plasma EBV viral load between EBV-associated HL and EBV-DNA positive normal people (P=0.490). Looking at patients' characteristics, plasma EBV viral load in 10-20 years EBV-associated HL was higher than in EBV cases which were less than 10 years or more than 35 years (P=0.025). Furthermore, in EBV-associated HL, concentration of plasma EBV-DNA was significantly higher in advanced stage disease (stages III-IV; P=0.013), and with B-symptoms (P=0.020). Conclusion: EBV-DNA levels were associated with part of clinicopathologic features of cases. It was of practical use to screen HL. Further etiological studies appear warranted.

#Hodgkin's lymphoma #Uygur nationality #nested-PCR #Epstein-Barr virus p1asma viral load

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