Clinical Implications of p57 Expression in Breast Cancer

Xu, Xiao-Yin; Wang, Wen-Qian; Zhang, Lei; Li, Yi-Ming; Tang, Miao; Jiang, Nan; Cai, Shou-Liang; Wei, Liang; Jin, Feng; Chen, Bo

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저자정보: Xu, Xiao-Yin (Department of Surgical Oncology and Department of Breast Surgery, the First Hospital of China Medical University) Wang, Wen-Qian (Department of Surgical Oncology and Department of Breast Surgery, the First Hospital of China Medical University) Zhang, Lei (Department of Surgical Oncology and Department of Breast Surgery, the First Hospital of China Medical University) Li, Yi-Ming (Department of Surgical Oncology and Department of Breast Surgery, the First Hospital of China Medical University) Tang, Miao (Department of Surgical Oncology and Department of Breast Surgery, the First Hospital of China Medical University) Jiang, Nan (Department of Surgical Oncology and Department of Breast Surgery, the First Hospital of China Medical University) Cai, Shou-Liang (Department of Surgical Oncology and Department of Breast Surgery, the First Hospital of China Medical University) Wei, Liang (Department of Surgical Oncology and Department of Breast Surgery, the First Hospital of China Medical University) Jin, Feng (Department of Surgical Oncology and Department of Breast Surgery, the First Hosp) Chen, Bo

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제10호

발행연도: 2012.1

수록면: 5,033 - 5,036 (4page)

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Objective: To study the relationship between expression of $p57^{KIP2}$ and prognosis and other clinicopathological parameters in invasive breast cancers. Methods: We assessed the expression of $p57^{KIP2}$ in 89 cases of invasive breast cancer and 20 cases of normal breast tissue by immunohistochemical methods and analyzed the results with SPSS software (ver. 16.0). Result: The positive expression rates of $p57^{KIP2}$ protein in the invasive breast cancers and surrounding normal tissue were 30.3% (27/89) and 65% (13/20), respectively. Cases with no $p57^{KIP2}$ expression exhibited a significantly higher post-operative distant metastasis rate than those with $p57^{KIP2}$ expression (37.9% vs. 14.8%; P = 0.01). DFS analysis showed that $p57^{KIP2}$-/C-erbB-2+ tumors also exhibited a significantly higher post-operative distant metastasis rate than the other groups (66.7% vs. 29.2%; P = 0.007), as did $p57^{KIP2}$-/p53+ tumors (64.3% vs. 22.7%; P = 0.001). Survival analysis revealed that $p57^{KIP2}$ was associated with breast cancer-specific survival overall (P = 0.045, log-rank test). Subgroup analysis demonstrated that individuals with $p57^{KIP2}$-/C-erbB-2+tumors experienced significantly worse post-operative survival than those with $p57^{KIP2}$-/C-erbB-2- or other tumors (P = 0.006, log-rank test). $p57^{KIP2}$-/p53+ tumors were associated with significantly worse post-operative survival than $p57^{KIP2}$-/p53- or other tumors (P = 0.001, log-rank test). Cox regression analysis showed that $p57^{KIP2}$ was a non-independent prognostic factor for breast cancer (P = 0.303). Conclusions: $p57^{KIP2}$ is expressed at low levels in invasive breast cancer and is associated with better overall survival rate and disease-free survival in breast cancer patients, but it was a non-independent prognostic factor for breast cancer. Thus, the connection between $p57^{KIP2}$/p53 and $p57^{KIP2}$/C-erbB-2 may provide biomarkers for breast cancer.

#Breast cancer #$p57^{KIP2}$ #biomarker

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