Association Between the Ku70-1310C/G Promoter Polymorphism and Cancer Risk: a Meta-analysis

Xu, Lu; Ju, Xiao-Bing; Li, Pu; Wang, Jue; Shi, Zhu-Mei; Zheng, Ming-Jie; Xue, Dan-Dan; Xu, Yan-Jie; Yin, Yong-Mei; Wang, Shui; You, Yong-Ping

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자료유형: 학술저널

저자정보: Xu, Lu (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) Ju, Xiao-Bing (Department of Urology, The First Affiliated Hospital with Nanjing Medical University) Li, Pu (Department of Urology, The First Affiliated Hospital with Nanjing Medical University) Wang, Jue (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) Shi, Zhu-Mei (Department of Neurosurgery, The First Affiliated Hospital with Nanjing Medical University) Zheng, Ming-Jie (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) Xue, Dan-Dan (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) Xu, Yan-Jie (Department of Medical Oncology, The First Affiliated Hospital with Nanjing Medical University) Yin, Yong-Mei (Department of Medical Oncology, The First Affiliated Hospital with Nanjing Medical University) Wang, Shui (Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University) You, Yong-Ping (Department of Neurosurgery, The First Affiliated Hospital with Nanjing M)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제2호

발행연도: 2012.1

수록면: 683 - 687 (5page)

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Ku70 plays an important role in DNA double-strand break repair. Studies revealing conflicting results on the role of the Ku70-1310C/G promoter polymorphism on cancer risk led us to perform a meta-analysis to investigate this relationship. Ten case-control studies with 2566 cases and 3058 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. The overall results suggested no association between the Ku70-1310C/G promoter polymorphism and total cancer risk. However, on stratified analysis, significantly increased risks were observed among the Asian population (GG vs. CC: OR=1.50, 95%CI=1.10-2.06; GG vs. CC/CG: OR=1.47, 95%CI=1.07-2.01) and population-based case-control studies (GG vs. CC: OR=1.57, 95%CI=1.12-2.22; CG vs. CC: OR=1.35, 95%CI=1.11-1.64; CG/GG vs. CC: OR=1.37, 95%CI=1.14-1.65). Additionally, variant genotypes were associated with a significantly increased breast cancer risk (GG vs. CC: OR=1.80, 95%CI=1.26-2.56; GG vs. CC/CG: OR=1.40, 95%CI=1.01-1.95).

#Ku70 #polymorphism #cancer #meta-analysis #carcinogenesis

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Xu, Lu

소속기관 Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University