Use of Oral Antidiabetic Drugs (Metformin and Pioglitazone) in Diabetic Patients with Breast Cancer: How Does It Effect on Serum Hif-1 Alpha and 8Ohdg Levels?

Ece, Harman; Cigdem, Erten; Yuksel, Kucukzeybek; Ahmet, Dirican; Hakan, Er; Oktay, Tarhan Mustafa

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자료유형: 학술저널

저자정보: Ece, Harman (Department of Endocrinology and Metabolism Disease, Katip Celebi University, Izmir Ataturk Training and Research Hospital) Cigdem, Erten (Department of Medical Oncology, Katip Celebi University, Izmir Ataturk Training and Research Hospital) Yuksel, Kucukzeybek (Department of Medical Oncology, Katip Celebi University, Izmir Ataturk Training and Research Hospital) Ahmet, Dirican (Department of Medical Oncology, Katip Celebi University, Izmir Ataturk Training and Research Hospital) Hakan, Er (Department of Microbiology, Katip Celebi University, Izmir Ataturk Training and Research Hospital) Oktay, Tarhan Mustafa (Department of Medical Oncology, Katip Celebi University, Izmir Ataturk Training and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제10호

발행연도: 2012.1

수록면: 5,143 - 5,148 (6page)

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Objective: The aim was to investigate indicators related to DNA damage and cancer pathogenesis in Type II diabetes cases with breast cancer. It was planned to evaluate the relationship between these markers with oral antidiabetic drugs. Research Design and Methods: Fourty patients and 10 healthy individuals were included in the study. HIF-$1{\alpha}$ and 8-OHdG are examined in blood samples taken from these individuals with an ELISA Kit. Statistical analysis of data was performed with 95% confidence using Windows package program SPSS 15.0. Results: HIF-$1{\alpha}$ parameters were found to be meaningfully higher in the patient group than the controls in both pretreatment and posttreatment periods (p<0.05). No significant differences in terms of 8-OHdG between patients and controls. However, posttreatment serum HIF-$1{\alpha}$ ve 8-OHdG levels was found lower than pretreatment levels in patients receiving metformin, but not with pioglitazone. Conversely, serum 8-OHdG levels decreased significantly in these patients. When patients were evaluated according to the treatment groups (pioglitazone vs. metfformin) no significant differences in terms of serum HIF-$1{\alpha}$ and 8-OHdG levels between treatment groups. Conclusions: HIF-$1{\alpha}$ levels decreased significantly in the patient group receiving metformin. However, there was no significant difference in terms of HIF-$1{\alpha}$ levels in the patients receiving pioglitazone.

#Breast cancer #diabetes #8-OhdG #HIF- $1{alpha}$ levels

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Ece, Harman

소속기관 Department of Endocrinology and Metabolism Disease, Katip Celebi University, Izmir Ataturk Training