Prognostic Significance of Two Dimensional AgNOR Evaluation in Local Advanced Rectal Cancer Treated with Chemoradiotherapy

Gundog, Mete; Yildiz, Oguz G; Imamoglu, Nalan; Aslan, Dicle; Aytekin, Aynur; Soyuer, Isin; Soyuer, Serdar

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자료유형: 학술저널

저자정보: Gundog, Mete (Departmentof Radiation Oncology, Kayseri Education and Research Hospital, University of Erciyes) Yildiz, Oguz G (Departmentof Radiation Oncology, Kayseri Education and Research Hospital, University of Erciyes) Imamoglu, Nalan (Department of Basic Pharmaceutical Sciences, Kayseri Education and Research Hospital, University of Erciyes) Aslan, Dicle (Departmentof Radiation Oncology, Kayseri Education and Research Hospital, University of Erciyes) Aytekin, Aynur (Department of Radiation Oncology, Kayseri Education and Research Hospital, University of Erciyes) Soyuer, Isin (Department of Pathology, Kayseri Education and Research Hospital, University of Erciyes) Soyuer, Serdar (Departmentof Radiation Oncology, Kayseri Education and Research Hospital, University of Erciyes)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제18호

발행연도: 2015.1

수록면: 8,155 - 8,161 (7page)

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The prognostic significance of AgNOR proteins in stage II-III rectal cancers treated with chemoradiotherapy was evaluated. Silver staining was applied to the $3{\mu}m$ sections of parafin blocked tissues from 30 rectal cancer patients who received 5-FU based chemoradiotherapy from May 2003 to June 2006. The microscopic displays of the cells were transferred into the computer via a video camera. AgNOR area (nucleolus organizer region area) and nucleus area values were determined as a nucleolus organizer regions area/total nucleus area (NORa/TNa). The mean NORa/TNa value was found to be $9.02{\pm}3.68$. The overall survival and disease free survival in the high NORa/TNa (>9.02) patients were 52.2 months and 39.4 months respectively, as compared to 100.7 months and 98.4 months in the low NORa/TNa (<9.02) cases. (p<0.001 and p<0.001 respectively). In addition, the prognosis in the high NORa/TNa patients was worse than low NORa/TNa patients (p<0.05). In terms of overall survival and disease-free survival, a statistically significant negative correlation was found with the value of NORa/TNa in the correlations tests. Cox regression analyses demostrated that overall survival and disease-free survival were associated with lymph node status (negative or positive) and the NORa/TNa value. We suggest that two-dimensional AgNOR evaluation may be a safe and usable parameter for prognosis and an indicator of cell proliferation instead of AgNOR dots.

#Two-dimensional AgNOR #chemoradiotherapy #morphometry #rectal cancer

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Gundog, Mete

소속기관 Departmentof Radiation Oncology, Kayseri Education and Research Hospital, University of Erciyes