지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 95 - 98 (4page)
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초록· 키워드
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Streptococcus suis (S. suis) is a major swine pathogen and an emerging zoonotic agent and is an increasing public health problem across Asia. The present study was undertaken to estimate the antibacterial effect of GR extract and therapeutic effect of GR extract against S. suis infection in mice. At the concentration of GR extract 2.5 mg/ml, the antibacterial effect was not shown on S. suis. However, the antibacterial effect against S. suis was observed at the concentration of GR extract 5.0 mg/ml. Oral administration of GR extract at the dose of 10 mg/kg showed a therapeutic effect for S. suis infected BALB/c mice. The mortality of GR extract-treated mice at the concentration of 5, 10 and 20 mg/kg was 80%, 70%, and 50% at 12 days, respectively, while that of untreated mice was 100% at 8 days after a lethal dose of S. suis infection. The results of our study strongly indicate that GR extract has potential as an effective for S. suis infection in mice.
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참고문헌 (31)
참고문헌 신청
Wisselink, H. J. / 2006 / Quantitative susceptibility of Streptococcus suis strains isolated from diseased pigs in Seven European countries to antimicrobial agents licensed in veterinary medicine / Vet. Microbiol 113:73~82
Kin, g S. J. / 2001 / Distribution and genetic diversity of suilysin in Streptococcus suis isolated from different diseases of pigs and characterization of the genetic basis of suilysin absence / Infect. Immun 69:7572~7582
Robertson, I. D. / 1989 / Prevalence of Streptococcus suis types 1 and 2 in domestic pigs in Australia and New Zealand / Vet. Rec 124:391~394
Gottschalk, M. / 2000 / The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions / Vet. Microbiol 76:259~272
Sriskandan, S. / 2006 / Invasive disease and toxic shock due to zoonotic Streptococcus suis: an emerging infection in the East? / PLoS Med 3:e187
Kin, g S. J. / 2001 / Distribution and genetic diversity of suilysin in Streptococcus suis isolated from different diseases of pigs and characterization of the genetic basis of suilysin absence / Infect. Immun 69:7572~7582
Robertson, I. D. / 1989 / Prevalence of Streptococcus suis types 1 and 2 in domestic pigs in Australia and New Zealand / Vet. Rec 124:391~394
Gottschalk, M. / 2000 / The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions / Vet. Microbiol 76:259~272
Sriskandan, S. / 2006 / Invasive disease and toxic shock due to zoonotic Streptococcus suis: an emerging infection in the East? / PLoS Med 3:e187
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