Development of the DVH management software for the biologically-guided evaluation of radiotherapy plan

Kim, Bo-Kyong; Park, Hee-Chul; Oh, Dong-Ryul; Shin, Eun-Hyuk; Ahn, Yong-Chan; Kim, Jin-Sung; Han, Young-Yih

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자료유형: 학술저널

저자정보: Kim, Bo-Kyong (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Park, Hee-Chul (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Oh, Dong-Ryul (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Shin, Eun-Hyuk (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Ahn, Yong-Chan (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Kim, Jin-Sung (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Han, Young-Yih (Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine)

저널정보: 대한방사선종양학회 Radiation oncology journal : ROJ Radiation oncology journal : ROJ 제30권 제1호

발행연도: 2012.1

수록면: 43 - 48 (6page)

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Purpose: To develop the dose volume histogram (DVH) management software which guides the evaluation of radiotherapy (RT) plan of a new case according to the biological consequences of the DVHs from the previously treated patients. Materials and Methods: We determined the radiation pneumonitis (RP) as an biological response parameter in order to develop DVH management software. We retrospectively reviewed the medical records of lung cancer patients treated with curative 3-dimensional conformal radiation therapy (3D-CRT). The biological event was defined as RP of the Radiation Therapy Oncology Group (RTOG) grade III or more. Results: The DVH management software consisted of three parts (pre-existing DVH database, graphical tool, and $Pinnacle^3$ script). The pre-existing DVH data were retrieved from 128 patients. RP events were tagged to the specific DVH data through retrospective review of patients' medical records. The graphical tool was developed to present the complication histogram derived from the preexisting database (DVH and RP) and was implemented into the radiation treatment planning (RTP) system, $Pinnacle^3$ v8.0 (Phillips Healthcare). The software was designed for the pre-existing database to be updated easily by tagging the specific DVH data with the new incidence of RP events at the time of patients' follow-up. Conclusion: We developed the DVH management software as an effective tool to incorporate the phenomenological consequences derived from the pre-existing database in the evaluation of a new RT plan. It can be used not only for lung cancer patients but also for the other disease site with different toxicity parameters.

#Radiotherapy #Dose volume histogram #Normal tissue complication probability

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