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논문 기본 정보

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학술저널
저자정보
Park, Hyun-Ji (Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) Kim, Jun-Hyeong (Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) Kang, Bong-Su (Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) Nam, Sang-Yoon (Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) Kim, Jong-Soo (Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) Jeong, Jae-Hwang (Department of Biotechnology and Biomedicine, Chungbuk Province College) Kim, Eun-Young (Department of Hotel Food Service & Culinary Arts, Youngdong University) Lee, Beom-Jun (Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Uni) Yun, Young-Won
저널정보
한국식품위생안전성학회 한국식품위생안전성학회지 한국식품위생안전성학회지 제26권 제4호
발행연도
2011.1
수록면
388 - 397 (10page)

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Selenium (Se) is known to prevent from several cancers, while iron (Fe) is known to be associated with high risk of cancers. The role of Se on colon carcinogenesis was investigated in an animal model induced by azoxymethane (AOM) and dextran sodium sulfate (DSS) in low Fe mice. Six-week old ICR mice fed on a low Fe diet (4.5 ppm Fe; generally 10 times lower than normal Fe) with three different Se (0.02, 0.1 or 0.5 ppm) levels for 24 weeks. The animals received weekly three ($0{\sim}2^{nd}$ weeks) i.p. injections of AOM (10 mg/kg RW), followed by 2% DSS with drinking water for 1 week to induce the colon cancer. There were five experimental groups including vehicle, positive control (normal Fe level, AOM/DSS), Low Fe (LFe) + AOM/DSS+Low Se (LSe), LFe + AOM/DSS + medium Se (MSe) and LFe + AOM/DSS + high Se (HSe) groups. HSe group showed a 66.7% colonic tumor incidence, MSe group showed a 69.2% tumor incidence, and LSe group showed a 80.0% tumor incidence. The tumor incidence was negatively associated with Se levels of diets. Tumor multiplicity in Hse group was significantly low compared to the other groups (p < 0.05). With increasing Se levels of diets, the primary anti-proliferating cell nuclear antigen (PCNA)-positive cells were decreased and apoptotic bodies were increased in a dose-dependent manner. Se-dependent glutathione peroxidase activity and its protein level were dependent on the levels of Se of diets. Malondialdehyde level in liver was lowest in Hse group among experimental groups. These findings indicate that dietary Se is chemopreventive for colon cancer by increasing antioxidant activity and decreasing cell proliferation in Fe-deficient mice.
#Selenium #Iron #Colon cancer #Azoxymethane #Dextran sodium sulfate

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참고문헌 (30)

참고문헌 신청
Tanaka, T. / 2003 / A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate / Cancer Sci 94:965~973 google schola Jemal, A / 2009 / Cancer statistics / Ca-Cancer J. Clin 59:225~249 google schola Okayasu, I. / 1990 / A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice / Gastroenterology 98:694~702 google schola Rosenberg, D.W. / 2009 / Mouse models for the study of colon carcinogenesis / Carcinogenesis 30:183~196 google schola Bruce, W.R / 2000 / Possible mechanisms relating diet and risk of colon cancer / Cancer Epidemiol. Biomarkers Prev 9:1271~1279 google schola

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