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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 187 - 191 (5page)
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초록· 키워드
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Platelet derived growth factor (PDGF)-BB is one of the most potent vascular smooth muscle cell(VSMC) proliferative factors, and abnormal VSMC proliferation by PDGF-BB plays an important role in the development and progression of atherosclerosis. The aim of this study was to assess the effect of YP 12, a newly synthesized obovatol derivative, on the proliferation of PDGF-BB-stimulated rat aortic VSMCs. The anti-proliferative effects of YP 12 on rat aortic VSMCs were examined by direct cell counting and by using $[^3H]$ thymidine incorporation assays. It was found that YP 12 potently inhibited the growth of VSMCs. The pre-incubation of YP 12 (1-4 ${\mu}M$) significantly inhibited the proliferation and DNA synthesis of 25 ng/ml PDGF-BB-stimulated rat aortic VSMCs in a concentration-dependent manner. In accordance with these findings, YP 12 revealed blocking of the PDGF-BB-inducible progression through G0/G1 to S phase of the cell cycle in synchronized cells. Whereas, YP 12 did not show any cytotoxicity in rat aortic VSMCs in this experimental condition by WST-1 assay. These results also show that YP 12 may have potential as an anti-proliferative agent for the treatment of restenosis and atherosclerosis.
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참고문헌 (19)
참고문헌 신청
Bornfeldt, K. E / 1995 / Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation / Ann N Y Acad Sci 766:416~430
Braun-Dullaeus, R. C. / 1998 / Cell cycle progression: new therapeutic target for vascular proliferative disease / Circulation 98(1):82~89
Chamley, J. H. / 1977 / Comparison of vascular smooth muscle cells from adult human, monkey and rabbit in primary culture and in subculture / Cell Tissue Res 177(4):503~522
Claesson-Welsh, L / 1994 / Platelet-derived growth factor receptor signals / J Biol Chem 269(51):32023~32026
Dzau, V. J. / 2002 / Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies / Nat Med 8(11):1249~1256
Braun-Dullaeus, R. C. / 1998 / Cell cycle progression: new therapeutic target for vascular proliferative disease / Circulation 98(1):82~89
Chamley, J. H. / 1977 / Comparison of vascular smooth muscle cells from adult human, monkey and rabbit in primary culture and in subculture / Cell Tissue Res 177(4):503~522
Claesson-Welsh, L / 1994 / Platelet-derived growth factor receptor signals / J Biol Chem 269(51):32023~32026
Dzau, V. J. / 2002 / Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies / Nat Med 8(11):1249~1256
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