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학술저널
저자정보
Lim, Hyeon Woo (Proton Therapy Center, Research Institute and Hospital, National Cancer Center) Kim, Tae Hyun (Proton Therapy Center, Research Institute and Hospital, National Cancer Center) Choi, Il Ju (Center for Gastric Cancer, Research Institute and Hospital, National Cancer Center) Kim, Chan Gyoo (Center for Gastric Cancer, Research Institute and Hospital, National Cancer Center) Lee, Jong Yeul (Center for Gastric Cancer, Research Institute and Hospital, National Cancer Center) Cho, Soo Jeong (Center for Gastric Cancer, Research Institute and Hospital, National Cancer Center) Eom, Hyeon Seok (Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center) Moon, Sung Ho (Proton Therapy Center, Research Institute and Hospital, National Cancer Center) Kim, Dae Yong (Proton Therapy Center, Research Institute and Hospital, National Cancer Center)
저널정보
대한방사선종양학회 Radiation oncology journal : ROJ Radiation oncology journal : ROJ 제34권 제3호
발행연도
2016.1
수록면
193 - 201 (9page)

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Purpose: To assess the clinical outcomes of radiotherapy (RT) using two-dimensional (2D) and three-dimensional conformal RT (3D-CRT) for patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma to evaluate the effectiveness of involved field RT with moderate-dose and to evaluate the benefit of 3D-CRT comparing with 2D-RT. Materials and Methods: Between July 2003 and March 2015, 33 patients with stage IE and IIE gastric MALT lymphoma received RT were analyzed. Of 33 patients, 17 patients (51.5%) were Helicobacter pylori (HP) negative and 16 patients (48.5%) were HP positive but refractory to HP eradication (HPE). The 2D-RT (n = 14) and 3D-CRT (n = 19) were performed and total dose was 30.6 Gy/17 fractions. Of 11 patients who RT planning data were available, dose-volumetric parameters between 2D-RT and 3D-CRT plans was compared. Results: All patients reached complete remission (CR) eventually and median time to CR was 3 months (range, 1 to 15 months). No local relapse occurred and one patient died with second primary malignancy. Tumor response, survival, and toxicity were not significantly different between 2D-RT and 3D-CRT (p > 0.05, each). In analysis for dose-volumetric parameters, $D_{max}$ and CI for PTV were significantly lower in 3D-CRT plans than 2D-RT plans (p < 0.05, each) and $D_{mean}$ and V15 for right kidney and $D_{mean}$ for left kidney were significantly lower in 3D-CRT than 2D-RT (p < 0.05, each). Conclusion: Our data suggested that involved field RT with moderate-dose for gastric MALT lymphoma could be promising and 3D-CRT could be considered to improve the target coverage and reduce radiation dose to the both kidneys.

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