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논문 기본 정보

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저자정보
Cha, Hyejung (Department of Radiation Oncology, Yonsei University College of Medicine) Kim, Jun Won (Department of Radiation Oncology, Yonsei University College of Medicine) Suh, Chang-Ok (Department of Radiation Oncology, Yonsei University College of Medicine) Kim, Jin Seok (Department of Internal Medicine, Yonsei University College of Medicine) Cheong, June-Won (Department of Internal Medicine, Yonsei University College of Medicine) Lee, Jeongshim (Department of Radiation Oncology, Yonsei University College of Medicine) Keum, Ki Chang (Department of Radiation Oncology, Yonsei University College of Medicine) Lee, Chang Geol (Department of Radiation Oncology, Yonsei University College of Medicine) Cho, Jaeho (Department of Radiation Oncology, Yonsei University College of Medicine)
저널정보
대한방사선종양학회 Radiation oncology journal : ROJ Radiation oncology journal : ROJ 제31권 제4호
발행연도
2013.1
수록면
177 - 184 (8page)

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Purpose: The aim of this study was to analyze the patterns of care and treatment outcomes in patients with primary thyroid lymphoma (PTL) in a single institution. Materials and Methods: Medical records of 29 patients with PTL treated between April 1994 and February 2012 were retrospectively reviewed. Diagnosis was confirmed by biopsy (n = 17) or thyroidectomy (n = 12). Treatment modality and outcome were analyzed according to lymphoma grade. Results: The median follow-up was 43.2 months (range, 3.8 to 220.8 months). The median age at diagnosis was 57 years (range, 21 to 83 years) and 24 (82.8%) patients were female. Twenty-five (86.2%) patients had PTL with stage IEA and IIEA. There were 8 (27.6%) patients with mucosa-associated lymphoid tissue (MALT) lymphoma and the remaining patients had high-grade lymphoma. Patients were treated with surgery (n = 2), chemotherapy (n = 7), radiotherapy (n = 3) alone, or a combination of these methods (n = 17). Treatment modalities evolved over time and a combination of modalities was preferred, especially for the treatment of high-grade lymphoma in recent years. There was no death or relapse among MALT lymphoma patients. Among high-grade lymphoma patients, 5-year overall survival (OS) and 5-year progression-free survival (PFS) were 75.6% and 73.9%, respectively. Complete remission after initial treatment was the only significant prognostic factor for OS (p = 0.037) and PFS (p = 0.003). Conclusion: Patients with PTL showed a favorable outcome, especially with MALT lymphoma. Radiotherapy alone for MALT lymphoma and chemotherapy followed by radiotherapy for high-grade lymphoma can be effective treatment options for PTL.
#Thyroid neoplasms #Non-Hodgkin lymphoma #Physician's practice pattern #Treatment outcome

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