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논문 기본 정보

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학술저널
저자정보
Lee, Yun Hee (Department of Radiation Oncology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine) Cho, Seok Goo (Department of Hematology, Catholic University Lymphoma Group [CULG], Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) Jung, Seung Eun (Department of Radiology, Catholic University Lymphoma Group [CULG], Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) Kim, Sung Hoon (Department of Nuclear Medicine, Catholic University Lymphoma Group [CULG], Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) O, Joo Hyun (Department of Nuclear Medicine, Catholic University Lymphoma Group [CULG], Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) Park, Gyeong Sin (Department of Pathology, Catholic University Lymphoma Group [CULG], Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) Yang, Suk Woo (Department of Ophthalmology, Catholic University Lymphoma Group [CULG], Seoul St. Mary's Hospital, Coll) Lee, In Seok Rhee, Chin Kook Choi, Byung Ock
저널정보
대한방사선종양학회 Radiation oncology journal : ROJ Radiation oncology journal : ROJ 제34권 제4호
발행연도
2016.1
수록면
273 - 279 (7page)

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Purpose: Although each Waldeyer's ring sub-site is considered an independent prognostic factor, few studies have assessed the prognosis and treatment of tonsillar lymphoma. Treatment outcomes were analyzed in patients with primary tonsillar lymphoma who were treated with chemotherapy and radiotherapy (RT). Materials and Methods: Nineteen patients with diffuse large B-cell lymphoma were evaluated, with a median follow-up of 53 months. Age, sex, and histology, amongst other factors, were reviewed. Progression-free survival (PFS) and overall survival (OS) rates were analyzed. Results: Most patients had Ann Arbor stage I-II (94.7%), IPI score of 0 (89.5%), and complete remission after chemotherapy (89.5%). The 5-year PFS and OS rates were 74.6% and 80%, respectively. In univariate analysis, the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen resulted in a better PFS than the cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen (88.9% vs. 50.0%; p = 0.053). RT dose was related to the survival outcome (p = 0.010 for PFS, p = 0.044 for OS). Patients were classified into the CHOP + RT (>40 Gy) group and R-CHOP + RT (${\leq}40Gy$) group. The 5-year PFS rates were 50% in the CHOP + RT group, and 100 % in the R-CHOP + RT group (p = 0.018). The 5-year OS rates were 66.7% and 100%, respectively (p = 0.087). Conclusion: Primary tonsillar lymphoma patients typically have favorable outcomes. Chemotherapy (R-CHOP) combined with relatively lower dose consolidative RT may be safe and effective for primary tonsillar lymphoma.

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