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논문 기본 정보

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학술저널
저자정보
Lee, Wan (Department of Oral and Maxillofacial Radiology and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University) Lee, Byung-Do (Department of Oral and Maxillofacial Radiology and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University) Lee, Kang-Kyoo (Department of Radiation Oncology, School of Medicine, Wonkwang University) Koh, Kwang-Joon (Department of Oral and Maxillofacial Radiology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University)
저널정보
대한영상치의학회 Imaging science in dentistry Imaging science in dentistry 제44권 제1호
발행연도
2014.1
수록면
43 - 52 (10page)

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Purpose: This study was designed to evaluate whether magnetic resonance imaging (MRI) is appropriate for detecting early changes in the mandibular bone marrow and pulp tissue of rats after high-dose irradiation. Materials and Methods: The right mandibles of Sprague-Dawley rats were irradiated with 10 Gy (Group 1, n=5) and 20 Gy (Group 2, n=5). Five non-irradiated animals were used as controls. The MR images of rat mandibles were obtained before irradiation and once a week until week 4 after irradiation. From the MR images, the signal intensity (SI) of the mandibular bone marrow and pulp tissue of the incisor was interpreted. The MR images were compared with the histopathologic findings. Results: The SI of the mandibular bone marrow had decreased on T2-weighted MR images. There was little difference between Groups 1 and 2. The SI of the irradiated groups appeared to be lower than that of the control group. The histopathologic findings showed that the trabecular bone in the irradiated group had increased. The SI of the irradiated pulp tissue had decreased on T2-weighted MR images. However, the SI of the MR images in Group 2 was high in the atrophic pulp of the incisor apex at week 2 after irradiation. Conclusion: These patterns seen on MRI in rat bone marrow and pulp tissue were consistent with histopathologic findings. They may be useful to assess radiogenic sclerotic changes in rat mandibular bone marrow.
#Magnetic Resonance Imaging #Mandible #Bone Marrow #Irradiation

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참고문헌 (27)

참고문헌 신청
Tofilon PJ / 2000 / The radioresponse of the central nervous system: a dynamic process / Radiat Res 153:357~370 google schola White SC / 2004 / Oral radiology; principles and interpretation / Mosby-Year Book :25~44 google schola Matsumura S / 1996 / Effect of X-ray irradiation on proliferation and differentiation of osteoblast / Calcif Tissue Int 59:307~308 google schola Sugimoto M / 1991 / Changes in bone after high-dose irradiation. Biomechanics and histomorphology / J Bone Joint Surg Br 73:492~497 google schola Moore GS / 1992 / Magnetic resonance imaging / Mosby-Year Book :2223~2274 google schola

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