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자료유형
학술저널
저자정보
Jung, You Jin (Department of Pediatrics, The Catholic University of Korea College of Medicine) Jeon, Yeon Jin (Department of Pediatrics, The Catholic University of Korea College of Medicine) Cho, Won Kyoung (Department of Pediatrics, The Catholic University of Korea College of Medicine) Lee, Jae Wook (Department of Pediatrics, The Catholic University of Korea College of Medicine) Chung, Nack-Gyun (Department of Pediatrics, The Catholic University of Korea College of Medicine) Jung, Min Ho (Department of Pediatrics, The Catholic University of Korea College of Medicine) Cho, Bin (Department of Pediatrics, The Catholic University of Korea College of Medicine) Suh, Byung-Kyu (Department of Pediatrics, The Catholic University of Korea College of Medicine)
저널정보
대한소아청소년과학회 Korean journal of pediatrics Korean journal of pediatrics 제56권 제7호
발행연도
2013.1
수록면
298 - 303 (6page)

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Purpose: The purpose of this study was to evaluate short-term thyroid dysfunction and related risk factors in pediatric patients who underwent hematopoietic stem cell transplantation (HSCT) during childhood. Methods: We studied 166 patients (100 boys and 66 girls) who underwent HSCT at the Catholic HSCT Center from January 2004 through December 2009. The mean age at HSCT was $10.0{\pm}4.8$ years. Thyroid function of the patients was tested before and during 3 months of HSCT. Results: Out of 166 patients, 165 (99.4%) underwent allotransplantation. Acute graft-versus-host disease (GVHD, grades II to IV) developed in 76 patients. Conditioning regimens before HSCT include total body irradiation (n=57), busulfan (n=80), and reduced intensity (n=29). Forty-five (27.1%) had thyroid dysfunction during 3 months after HSCT (29 euthyroid sick syndrome [ESS], 6 subclinical hyperthyroidism, 4 subclinical hypothyroidism, 3 hypothyroxinemia, 2 overt hyperthyroidism, and 1 high $T_4$ syndrome). In a univariate logistic regression analysis, age at HSCT (P=0.002) and acute GVHD (P=0.009) had statistically significant relationships with thyroid dysfunction during 3 months after HSCT. Also, in a univariate logistic regression analysis, ESS (P=0.014) showed a strong statistically significant association with mortality. Conclusion: In our study 27.1% patients experienced thyroid dysfunction during 3 months after HSCT. Increase in age and acute GVHD may be risk factors for thyroid dysfunction during 3 months after HSCT. There was a significant association between ESS and mortality.

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