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자료유형
학술저널
저자정보
Baek, Ji Hyeon (Department of Pediatrics, CHA Bundang Medical Center, CHA University) Seo, Hyun Kyong (Department of Pediatrics, CHA Bundang Medical Center, CHA University) Jee, Hye Mi (Department of Pediatrics, CHA Bundang Medical Center, CHA University) Shin, Youn Ho (Department of Pediatrics, CHA Bundang Medical Center, CHA University) Han, Man Yong (Department of Pediatrics, CHA Bundang Medical Center, CHA University) Oh, Eun Sang (College of Pharmacy, Ewha Womans University) Lee, Hyun Ju (Center for Vaccine Evaluation and Study, Medical Research Institute, Ewha Womans University) Kim, Kyung Hyo (Center for Vaccine Evaluation and Study, Medical Research Institute, Ewha Womans University)
저널정보
대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제56권 제7호
발행연도
2013.1
수록면
286 - 290 (5page)

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Purpose: Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis. Methods: We examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3-11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months or >3 times per year. The complete blood count with differential and total serum concentrations of Immunoglobulin (Ig) E, IgA, IgD, IgM, IgG, and IgG subclasses ($IgG_1$, $IgG_2$, $IgG_3$, and $IgG_4$) of all children were measured. All subjects received 23-polysaccharide pneumococcal vaccination (PPV), and the levels of antibodies to 5 serologic types (4, 6B, 14, 18C, and 23F) of pneumococcal capsular polysaccharide antigens were measured before and after vaccination. Post-PPV antibody titers ${\geq}0.35{\mu}g/mL$ or with a ${\geq}4$-fold increase were considered as positive responses. Results: The titers of IgG, IgA, IgD, and IgM were within normal range in all 16 children, whereas the total IgE concentration was higher than normal in 2 children. $IgG_1$ deficiency was observed in 1 patient and $IgG_3$ deficiency in 3. After PPV, 1 patient failed to respond to all 5 serologic types, 2 failed to respond to 4 serologic types, and 2 failed to respond to 3 serologic types. Conclusion: Clinicians should consider the evaluation of humoral immune functions in children with chronic or recurrent rhinosinusitis who do not respond to prolonged antibiotic treatment.

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