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학술저널
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Kim, Hyun O (Department of Pediatrics, The Catholic University of Korea College of Medicine) Oh, Hyun Jin (Department of Pediatrics, The Catholic University of Korea College of Medicine) Lee, Jae Wook (Department of Pediatrics, The Catholic University of Korea College of Medicine) Jang, Pil-Sang (Department of Pediatrics, The Catholic University of Korea College of Medicine) Chung, Nack-Gyun (Department of Pediatrics, The Catholic University of Korea College of Medicine) Cho, Bin (Department of Pediatrics, The Catholic University of Korea College of Medicine) Kim, Hack-Ki (Department of Pediatrics, The Catholic University of Korea College of Medicine)
저널정보
대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제56권 제1호
발행연도
2013.1
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26 - 31 (6page)

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Purpose: Lymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT). Temporal differences in the recovery of lymphocyte subsets and the factors influencing this recovery are important variables that affect a patient's posttransplant immune reconstitution, and therefore require investigation. Methods: The time taken to achieve lymphocyte subset recovery and the factors influencing this recovery were investigated in 59 children who had undergone HSCT at the Department of Pediatrics, The Catholic University of Korea Seoul St. Mary's Hospital, and who had an uneventful follow-up period of at least 1 year. Analyses were carried out at 3 and 12 months post-transplant. An additional study was performed 1 month post-transplant to evaluate natural killer (NK) cell recovery. The impact of pre- and post-transplant variables, including diagnosis of Epstein-Barr virus (EBV) DNAemia posttransplant, on lymphocyte recovery was evaluated. Results: The lymphocyte subsets recovered in the following order: NK cells, cytotoxic T cells, B cells, and helper T cells. At 1 month post-transplant, acute graft-versus-host disease was found to contribute significantly to the delay of $CD16^+/56^+$ cell recovery. Younger patients showed delayed recovery of both $CD3^+/CD8^+$ and $CD19^+$ cells. EBV DNAemia had a deleterious impact on the recovery of both $CD3^+$ and $CD3^+/CD4^+$ lymphocytes at 1 year post-transplant. Conclusion: In our pediatric allogeneic HSCT cohort, helper T cells were the last subset to recover. Younger age and EBV DNAemia had a negative impact on the post-transplant recovery of T cells and B cells.

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