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학술저널
저자정보
Eun, Ho Seon (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) Lee, Soon Min (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) Park, Min Soo (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) Park, Kook In (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) Namgung, Ran (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) Lee, Chul (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine)
저널정보
대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제56권 제11호
발행연도
2013.1
수록면
477 - 481 (5page)

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Purpose: Ureaplasma colonization is related with perinatal complications in preterm infants. Little is known about the difference in virulence among various Ureaplasma urealyticum serovars. The aim of this study was to determine U. urealyticum serovars of preterm infants in order to assess whether any of the serovars were associated with bronchopulmonary dysplasia (BPD). Methods: Three hundred forty-four preterm infants with a gestational age less than 34 weeks admitted to Gangnam Severance Hospital neonatal intensive care unit from July 2011 to December 2012 were included in this study. Tracheal and gastric aspirations were conducted on infants to confirm Ureaplasma colonization. Ureaplasma colonization was confirmed in 9% of infants, of these, serovars were determined by real-time polymerase chain reaction. Results: A total of 31 infants (gestational age, $29.3{\pm}3.1$ weeks; birth weight, $1,170{\pm}790g$) were U. urealyticum positive. The Ureaplasma positive group treated for more days with oxygen and ventilation than the negative group (P<0.05). Histologic chorioamnionitis and moderate to severe BPD were more frequent in the Ureaplasma positive group than in the negative group (P<0.05). U. urealyticum isolates were either found to be a mixture of multiple serovars (32%), serovar 9 alone or combined with other serovars (39%), serovar 11 (26%), 2 (13%), 8 (10%), 10 (13%), and 13 (25%). No individual serovars were significantly associated with moderate to severe BPD and chorioamnionitis. Conclusion: This is the first study to describe the distribution of U. urealyticum serovars from Korean preterm infants. Ureaplasma -colonized infants showed higher incidence of BPD and chorioamnionitis.

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