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논문 기본 정보

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학술저널
저자정보
Ji, Sun-Tae (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) Chueh, Hee-Won (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) Kim, Ju-Youn (Department of Childrens Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lim, Su-Jin (Department of Childrens Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) Cho, Eun-Joo (Department of Childrens Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lee, Soo-Hyun (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) Yoo, Keon-Hee (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) Sung, Ki-Woong (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) Koo, Hong-Hoe (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
저널정보
대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제54권 제3호
발행연도
2011.1
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128 - 132 (5page)

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Purpose: Cisplatin-based chemotherapy has been commonly used for the treatment of intracranial germ cell tumors (IC-GCTs). However, this treatment exhibits some adverse effects such as renal problems and hearing difficulty. Carboplatin-based chemotherapy was administered to pediatric patients with IC-GCTs from August 2004 at the Samsung Medical Center. In this study, we assessed the responses and adverse effects of carboplatin-based chemotherapy in pediatric IC-GCTs patients according to the risk group, and compared the results with those of the previous cisplatin-based chemotherapy. Methods: We examined 35 patients (27 men and 8 women) diagnosed with IC-GCTs between August 2004 and April 2008 and received risk-adapted carboplatin-based chemotherapy at the Samsung Medical Center. Patients were divided into either low-risk (LR) or high-risk (HR) groups and a retrospective analysis was performed using information from the medical records. Results: Although hematological complications were common, hearing difficulties or grade 3 or 4 creatinine level elevation were not observed in patients who underwent carboplatin-based chemotherapy. The frequency of febrile neutropenia did not differ between the risk groups. The overall survival was 100% and event-free survival (EFS) was 95.7%. The EFS rate was 100% in the LR group and 90% in the HR group, respectively. Conclusion: Despite their common occurrence in high-risk patients, no lethal hematological complications were associated with carboplatin-based treatment. The current carboplatin-based chemotherapy protocol is safe and effective for the treatment of pediatric patients with IC-GCTs.
#Intracranial germ cell tumor #Carboplatin #Adverse effects

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