Occurrence and characterization of oseltamivir-resistant influenza virus in children between 2007-2008 and 2008-2009 seasons

Kim, Seoung Geun; Hwang, Yoon Ha; Shin, Yung Hae; Kim, Sung Won; Jung, Woo Sik; Kim, Sung Mi; Oh, Jae Min; Lee, Na Young; Kim, Mun Ju; Cho, Kyung Soon; Park, Yeon Gyeong; Min, Sang Kee; Lee, Chang Kyu; Kim, Jun Sub; Kang, Chun; Lee, Joo Yeon; Huh, Man Kyu; Kim, Chang Hoon

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자료유형: 학술저널

저자정보: Kim, Seoung Geun (Department of Pediatrics, Busan St. Mary's Medical Center) Hwang, Yoon Ha (Department of Pediatrics, Busan St. Mary's Medical Center) Shin, Yung Hae (Department of Pediatrics, Busan St. Mary's Medical Center) Kim, Sung Won (Department of Pediatrics, Busan St. Mary's Medical Center) Jung, Woo Sik (Department of Pediatrics, Busan St. Mary's Medical Center) Kim, Sung Mi (Department of Pediatrics, Busan St. Mary's Medical Center) Oh, Jae Min (Department of Pediatrics, Busan St. Mary's Medical Center) Lee, Na Young (Department of Pediatrics, Busan St. Mary's Medical Center) Kim, Mun Ju (Department of Pediatrics, Busan St. Mary's Medical Center) Cho, Kyung Soon (Institute of Health & Environment) Park, Yeon Gyeong (Institute of Health & Environment) Min, Sang Kee (Institute of Health & Environment) Lee, Chang Kyu (Department of Laboratory Medicine, Korea University Anam Hospital) Kim, Jun Sub (Division of Influenza Virus, Korea Centers for Disease Control and Prevention) Kang, Chun (Division of Influenza Virus, Korea Centers for Disease Control and Prevention) Lee, Joo Yeon (Division of Influenza Virus, Korea Centers for Disease Control and Prevention) Huh, Man Kyu (Department of Molecular Biology, Dongeui Uni) Kim, Chang Hoon

저널정보: 대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제56권 제4호

발행연도: 2013.1

수록면: 165 - 175 (11page)

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Purpose: There was a global increase in the prevalence of oseltamivir-resistant influenza viruses during the 2007-2008 influenza season. This study was conducted to investigate the occurrence and characteristics of oseltamivir-resistant influenza viruses during the 2007-2008 and 2008-2009 influenza seasons among patients who were treated with oseltamivir (group A) and those that did not receive oseltamivir (group B). Methods: A prospective study was conducted on 321 pediatric patients who were hospitalized because of influenza during the 2007-2008 and 2008-2009 influenza seasons. Drug resistance tests were conducted on influenza viruses isolated from 91 patients. Results: There was no significant difference between the clinical characteristics of groups A and B during both seasons. Influenza A/H1N1, isolated from both groups A and B during the 2007-2008 and 2008-2009 periods, was not resistant to zanamivir. However, phenotypic analysis of the virus revealed a high oseltamivir $IC_{50}$ range and that H275Y substitution of the neuraminidase (NA) gene and partial variation of the hemagglutinin (HA) gene did not affect its antigenicity to the HA vaccine even though group A had a shorter hospitalization duration and fewer lower respiratory tract complications than group B. In addition, there was no significant difference in the clinical manifestations between oseltamivir-susceptible and oseltamivir-resistant strains of influenza A/H1N1. Conclusion: Establishment of guidelines to efficiently treat influenza with oseltamivir, a commonly used drug for treating influenza in Korean pediatric patients, and a treatment strategy with a new therapeutic agent is required.

#Influenza #Oseltamivir #Resistance #Child

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