지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제41권 제3호
- 발행연도
- 2014.1
- 수록면
- 97 - 107 (11page)
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초록· 키워드
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The placenta is a temporary fetomaternal organ capable of supporting fetal growth and development during pregnancy. In particular, abnormal development and dysfunction of the placenta due to cha nges in the proliferation, differentiation, cell death, and invasion of trophoblasts induce several gynecological diseases as well as abnormal fetal development. Autophagy is a catalytic process that maintains cellular structures by recycling building blocks derived from damaged microorganelles or proteins resulting from digestion in lysosomes. Additionally, autophagy is necessary to maintain homeostasis during cellular growth, development, and differentiation, and to protect cells from nutritional deficiencies or factors related to metabolism inhibition. Induced autophagy by various environmental factors has a dual role: it facilitates cellular survival in normal conditions, but the cascade of cellular death is accelerated by over-activated autophagy. Therefore, cellular death by autophagy has been known as programmed cell death type II. Autophagy causes or inhibits cellular death via the other mechanism, apoptosis, which is programmed cell death type I. Recently, it has been reported that autophagy increases in placenta-related obstetrical diseases such as preeclampsia and intrauterine growth retardation, although the mechanisms are still unclear. In particular, abnormal autophagic mechanisms prevent trophoblast invasion and inhibit trophoblast functions. Therefore, the objectives of this review are to examine the characteristics and functions of autophagy and to investigate the role of autophagy in the placenta and the trophoblast as a regulator of cell death.
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참고문헌 (74)
참고문헌 신청
Benischke K / 2000 / Pathology of the human placenta / Springer-Verlag
Moore KL / 2008 / The developing human-clinically orientated embryology. 8th ed / Saunders
Huppertz B / 2008 / The anatomy of the normal placenta / J Clin Pathol 61:1296~1302
Berry DL / 2008 / Autophagy functions in programmed cell death / Autophagy 4:359~360
Rikiishi H / 2012 / Novel Insights into the Interplay between Apoptosis and Autophagy / Int J Cell Biol 2012:317645
Moore KL / 2008 / The developing human-clinically orientated embryology. 8th ed / Saunders
Huppertz B / 2008 / The anatomy of the normal placenta / J Clin Pathol 61:1296~1302
Berry DL / 2008 / Autophagy functions in programmed cell death / Autophagy 4:359~360
Rikiishi H / 2012 / Novel Insights into the Interplay between Apoptosis and Autophagy / Int J Cell Biol 2012:317645
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