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논문 기본 정보

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학술저널
저자정보
Park, Chan-Woo (Division of Reproductive Endocrinology and Infertility, Cheil General Hospital, Kwandong University College of Medicine) Han, Ae-Ra (Division of Reproductive Endocrinology and Infertility, Cheil General Hospital, Kwandong University College of Medicine) Kim, Joanne-Kwak (Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science) Park, So-Yeon (Laboratory of Medical Genetics, Cheil General Hospital, Kwandong University College of Medicine) Han, Jung-Yeol (Division of Feto-maternal Medicine, Department of Obstetrics and Gynecology, Cheil General Hospital, Kwandong University College of Medicine) Koong, Mi-Kyoung (Division of Reproductive Endocrinology and Infertility, Cheil General Hospital, Kwandong University College of Medicine) Song, In-Ok (Division of Reproductive Endocrinology and Infertility, Cheil General Hospital, Kwandong University College of Medicine) Yang, Kwang-Moon (Division of Reproductive Endocrinology and Infertility, Cheil General Hospital, Kwandong University College of Medicine)
저널정보
대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제38권 제3호
발행연도
2011.1
수록면
168 - 173 (6page)

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Objective: To examine the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and hyperhomocysteinemia in women with unexplained recurrent miscarriages (RM) and to investigate the association between MTHFR genotype variants and alloimmune activation, proportion of peripheral blood natural killer (pbNK) cells. Methods: A total of 39 patients with a history of two or more unexplained miscarriages were recruited to this study. The controls were women who had a live birth without a history of RM (n=50). The proportion of pbNK cells was measured by flow cytometry. Plasma homocysteine levels and the incidence of the MTHFR variant of the RM and control groups were compared. The proportion of pbNK cells was compared to the MTHFR variants in the RM group. Results: No differences were found between the two groups' mean plasma homocysteine levels ($7.6{\pm}1.5{\mu}mol$/L vs. $7.1{\pm}2.1{\mu}mol$/L) or incidence of the MTHFR genotype variant (CC, 35% vs. 33%; CT, 40% vs. 53%; and TT, 25% vs. 14%). In the RM group, individuals with the TT variant ($7.7{\pm}1.1{\mu}mol$/L) had higher homocysteine levels than those with the CC and CT variants ($7.4{\pm}1.9{\mu}mol$/L and $7.4{\pm}1.2{\mu}mol$/L) and those with the CT variant ($19.2{\pm}8.1%$) had a higher proportion of CD3-/CD56+ pbNK cells than those with the CC and TT variants ($17.7{\pm}6.6%$ and $17.9{\pm}7.0%$), but the results of both comparisons were statistically insignificant. Conclusion: These preliminary results show no difference in plasma homocysteine levels between the RM and control groups or among MTHFR genotype variants in the RM group, which may suggest that the plasma homocysteine level is difficult to use as a predictive marker of RM in the Korean population. A study of a larger number of patients is needed.
#Methylenetetrahydrofolate Reductase Polymorphism #Habitual Abortion #Natural Killer Cells #Human

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참고문헌 (28)

참고문헌 신청
Strobino B / 1986 / Characteristics of women with recurrent spontaneous abortions and women with favorable reproductive histories / Am J Public Health 76:986~991 google schola Steegers-Theunissen RP / 1992 / Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae / Lancet 339:1122~1123 google schola Wouters MG / 1993 / Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss / Fertil Steril 60:820~825 google schola Nelen WL / 2000 / Hyperhomocysteinemia and recurrent early pregnancy loss: a metaanalysis / Fertil Steril 74:1196~1199 google schola Nelen WL / 1997 / Genetic risk factor for unexplained recurrent early pregnancy loss / Lancet 350:861 google schola

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