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논문 기본 정보

자료유형
학술저널
저자정보
Faramarzi, Azita (Department of Physiology, School of Medicine, Tehran University of Medical Science) Seifi, Behjat (Department of Physiology, School of Medicine, Tehran University of Medical Science) Sadeghipour, Hamid Reza (Department of Physiology, School of Medicine, Tehran University of Medical Science) Shabanzadeh, Alireza (Department of Physiology, School of Medicine, Tehran University of Medical Science) Ebrahimpoor, Mitra (Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science)
저널정보
대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제39권 제2호
발행연도
2012.1
수록면
81 - 86 (6page)

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Objective: Sterilization (tubal sterilization and vasectomy) is a widely applied contraceptive method worldwide. Although most studies have described sterilization as a safe method, there are reports of tubal ligation (TL) and vasectomy complications. The aim of this study was to evaluate the effects of TL and vasectomy on the serum oxidative stress, specifically prooxidant-antioxidant balance (PAB) and malondialdehyde (MDA) levels, over time. Methods: Male and female rats were classified into vasectomy, sham-vasectomy, TL, and sham-TL groups, respectively. The PAB and MDA levels were measured on days 15 and 45 and months 3 and 6 after the intervention. For female rats, blood sampling was performed during the diestrous phase and estradiol and progesterone were also measured. Results: Serum PAB and MDA increased after TL (p<0.05). Vasectomy increased serum MDA remarkably after 45 days, 3 months, and 6 months (p<0.05). After vasectomy, serum PAB also increased although not significantly. Serum estradiol and progesterone decreased remarkably in the TL group compared to the sham group (p<0.05). Conclusion: Bilateral TL and vasectomy both increase the serum oxidative stress; however the imbalance after TL was very noticeable. As for the TL, the reduction of serum estrogen levels can be involved in this imbalance. Complications followed by TL or vasectomy could be due to increased levels of oxidants. Thus, prescribing antioxidants during and or after surgery may be a solution.

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