지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제40권 제2호
- 발행연도
- 2013.1
- 수록면
- 100 - 105 (6page)
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초록· 키워드
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Objective: The aim of this study was to investigate the effect of insulin sensitizing agents on hormonal and metabolic parameters as well as menstrual patterns in women with polycystic ovary syndrome (PCOS). Methods: One hundred and twenty-three patients with PCOS were included. Metformin was administered to patients at 1,500 mg or 1,700 mg daily for 3 months. If the patients had no improvement of the menstrual cycle or metformin-related adverse effects developed, the patients changed medication to a daily dose of either 15 mg pioglitazone or up to 45 mg. Then resumption of a regular menstrual cycle or recovery of ovulation was evaluated. Hormonal and metabolic profiles were compared between the response and non-response group to insulin sensitizing agents. Results: One hundred and five patients with PCOS were treated with metformin for 3 months. Forty-eight patients (45.7%) showed improvement of menstrual cycle regularity after 3 months of metformin use, whereas 57 patients (54.3%) had no change. The mean free testosterone measured after 3 months of treatment was significantly lower in metformin responders than in non-responders. The other parameters did not differ between the groups. Of the 23 patients who used pioglitazone for 3 to 6 months, 19 patients (82.6%) showed improvement in their menstrual cycles. Conclusion: Metformin treatment seems to be effective for the improvement of menstrual cyclicity irrespective of insulin resistance in women with PCOS. When metformin related adverse effect occurred, pioglitazone would be effective for aiding the resumption of the menstrual cycle.
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참고문헌 (28)
참고문헌 신청
Azziz R / 2004 / The prevalence and features of the polycystic ovary syndrome in an unselected population / J Clin Endocrinol Metab 89:2745~2749
Dunaif A / 1995 / Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome / J Clin Invest 96:801~810
Dunaif A / 1997 / Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis / Endocr Rev 18:774~800
Li M / 2002 / Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators / J Clin Endocrinol Metab 87:4088~4093
Diamanti-Kandarakis E / 2006 / Insulin resistance in PCOS / Endocrine 30:13~17
Dunaif A / 1995 / Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome / J Clin Invest 96:801~810
Dunaif A / 1997 / Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis / Endocr Rev 18:774~800
Li M / 2002 / Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators / J Clin Endocrinol Metab 87:4088~4093
Diamanti-Kandarakis E / 2006 / Insulin resistance in PCOS / Endocrine 30:13~17
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