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논문 기본 정보

자료유형
학술저널
저자정보
Choi, Kyoung-Hee (Fertility Center of CHA Gangnam Medical Center, CHA University College of Medicine) Lee, Jung-Hyun (Fertility Center of CHA Gangnam Medical Center, CHA University College of Medicine) Yang, Yun-Hee (Fertility Center of CHA Gangnam Medical Center, CHA University College of Medicine) Yoon, Tae-Ki (Fertility Center of CHA Gangnam Medical Center, CHA University College of Medicine) Lee, Dong-Ryul (Fertility Center of CHA Gangnam Medical Center, CHA University College of Medicine) Lee, Woo-Sik (Fertility Center of CHA Gangnam Medical Center, CHA University College of Medicine)
저널정보
대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제38권 제3호
발행연도
2011.1
수록면
148 - 152 (5page)

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Objective: Laser-assisted intracytoplasmic sperm injection (LA-ICSI), also known as micro-opening or thinning of the zona pellucida (ZP) prior to ICSI, may help to reduce mechanical damage to the oocyte during the procedure. The aim of the present study was to evaluate and analyze the efficacy of our institutional LA-ICSI program, which features laser-assisted ZP thinning prior to ICSI, in comparison with conventional ICSI (C-ICSI), performed on patients with different clinical characteristics. Methods: Patients undergoing a total of 212 ICSI cycles were randomly divided into an LA-ICSI group (106 cycles) and a conventional ICSI group (106 cycles). To reduce tissue damage, we thinned the ZP by approximately 70%, using a laser, before ICSI. Patients thus treated formed the LAICSI group. Comparisons included the morphological quality of transferred embryos, blastocyst development of the remaining embryos, and clinical pregnancy, in terms of ICSI method and patient characteristics. Results: Fertilization, development of remaining embryos, and pregnancy rate were significantly higher in the LA-ICSI group compared with the C-ICSI group. Fertilization, embryonic development, and the pregnancy rate were all improved in younger patients (<38 years of age) and in those who underwent a low number of IVF-ET attempts (<3 trials). In addition, the pregnancy rate was increased in older patients. Conclusion: LA-ICSI may be useful in improving the chance of pregnancy in all ICSI patients.
#Intracytoplasmic Sperm Injection #Laser-assisted Intracytoplasmic Sperm Injection #In Vitro Fertilization-embryo Transfer #Zona Pellucida Thinning #Clinical Outcome #Human

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참고문헌 (21)

참고문헌 신청
Palermo G / 1992 / Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte / Lancet 340:17~18 google schola Ebner T / 2004 / Complete oocyte activation failure after ICSI can be overcome by a modified injection technique / Hum Reprod 19:1837~1841 google schola Ola B / 2001 / Should ICSI be the treatment of choice for all cases of in-vitro conception? Considerations of fertilization and embryo development, cost effectiveness and safety / Hum Reprod 16:2485~2490 google schola Oehninger S / 2002 / Should ICSI be the treatment of choice for all cases of in-vitro conception? No, not in light of the scientific data / Hum Reprod 17:2237~2242 google schola Bhattacharya S / 2001 / Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial / Lancet 357:2075~2079 google schola

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