Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET

Kim, Jee-Hyun; Shin, Mi-Sun; Yi, Gwang; Jee, Byung-Chul; Lee, Jung-Ryeol; Suh, Chang-Suk; Kim, Seok-Hyun

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자료유형: 학술저널

저자정보: Kim, Jee-Hyun (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) Shin, Mi-Sun (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) Yi, Gwang (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) Jee, Byung-Chul (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) Lee, Jung-Ryeol (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) Suh, Chang-Suk (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) Kim, Seok-Hyun (Department of Obstetrics and Gynecology, Seoul National University College of Medicine)

저널정보: 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제39권 제1호

발행연도: 2012.1

수록면: 28 - 32 (5page)

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Objective: This study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF. Methods: Between May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days post-ET and stored. HCG, progesterone, and inhibin A levels were measured by commercial enzyme-linked immunosorbent assay kits. The predictive accuracy of hCG, progesterone, and inhibin A levels for establishment of intrauterine pregnancy and ongoing pregnancy was calculated by receiver-operating characteristic curve analysis. Results: For the prediction of intrauterine and ongoing pregnancy, serum hCG was better than progesterone and inhibin A. The predictive performance of progesterone and inhibin A was similar. The serum progesterone and inhibin A levels were significantly correlated each other (r=0.915, p=0.010). Conclusion: A single measurement of the serum hCG level is sufficient to predict pregnancy outcome in IVF-ET patients.

#Chorionic gonadotropin #Progesterone #Inhibins #In vitro fertilization #Embryo transfer #Outcomes, pregnancy

참고문헌 (20)

참고문헌 신청

Simon C / 1999 / Early pregnancy losses in in vitro fertilization and oocyte donation / Fertil Steril 72:1061~1065

Ochsenkuhn R / 2009 / Predictive value of early serum beta-hCG levels after single blastocyst transfer / Acta Obstet Gynecol Scand 88:1382~1388

Poikkeus P / 2002 / Serum HCG 12 days after embryo transfer in predicting pregnancy outcome / Hum Reprod 17:1901~1905

Urbancsek J / 2002 / Serum human chorionic gonadotropin measurements may predict pregnancy outcome and multiple gestation after in vitro fertilization / Fertil Steril 78:540~542

Papageorgiou TC / 2001 / Human chorionic gonadotropin levels after blastocyst transfer are highly predictive of pregnancy outcome / Fertil Steril 76:981~987