지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제41권 제1호
- 발행연도
- 2014.1
- 수록면
- 21 - 28 (8page)
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초록· 키워드
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Objective: To investigate the association of individual follicular fluid (FF) leptin and adiponectin levels with the quality of the corresponding oocyte and embryo. Methods: We prospectively enrolled 67 women who underwent controlled ovarian hyperstimulation with 89 FF samples. FF and the corresponding oocyte was obtained from a single dominant preovulatory follicle at the time of oocyte retrieval. Concentrations of leptin and adiponectin were measured by enzyme-linked immunosorbent assay in an individual follicle. The oocyte quality, fertilization rate, and corresponding embryo development were assessed. Results: The FF level of leptin was significantly associated with body mass index (r=0.334, p<0.01). The FF adiponectin level was significantly higher in the normal fertilization group than the abnormal fertilization group (p=0.009) in the non-obese women. A lower FF leptin level was associated with a trend toward mature oocytes, normal fertilization, and good embryo quality, although these relationships were not statistically significant. The leptin:adiponectin ratio of FF did not differ significantly according to oocyte and embryo quality. The quality of the oocyte and embryo was not associated with the FF leptin level tertile. However, the normal fertilization rate was positively associated with FF adiponectin level tertile. There was a trend towards improved oocytes and normal fertilization rates with the lowest tertile of the FF leptin:adiponectin ratio, but this difference was not statistically significant. Conclusion: Our results suggest that a high FF adiponectin concentration could be a predictor of normal fertilization. However, the FF leptin concentration and leptin:adiponectin ratio is not significantly related to oocyte maturity and corresponding embryo development.
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참고문헌 (39)
참고문헌 신청
Dale PO / 2004 / Impact of overweight and underweight on assisted reproduction treatment / Hum Reprod 19:2523~2528
Metwally M / 2008 / Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence / Fertil Steril 90:714~726
Maheshwari A / 2007 / Effect of overweight and obesity on assisted reproductive technology: a systematic review / Hum Reprod Update 13:433~444
Lintsen AM / 2005 / Effects of subfertility cause, smoking and body weight on the success rate of IVF / Hum Reprod 20:1867~1875
Wang JX / 2000 / Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study / BMJ 321:1320~1321
Metwally M / 2008 / Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence / Fertil Steril 90:714~726
Maheshwari A / 2007 / Effect of overweight and obesity on assisted reproductive technology: a systematic review / Hum Reprod Update 13:433~444
Lintsen AM / 2005 / Effects of subfertility cause, smoking and body weight on the success rate of IVF / Hum Reprod 20:1867~1875
Wang JX / 2000 / Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study / BMJ 321:1320~1321
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