지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제41권 제4호
- 발행연도
- 2014.1
- 수록면
- 158 - 164 (7page)
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초록· 키워드
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Objective: To assess whether an early GnRH antagonist start leads to better follicular synchronization and an improved clinical pregnancy rate (CPR). Methods: A retrospective cohort study. A total of 218 infertile women who underwent IVF between January 2011 and February 2013. The initial cohort (Cohort I) that underwent IVF between January 2011 and March 2012 included a total of 68 attempted IVF cycles. Thirty-four cycles were treated with the conventional GnRH antagonist protocol, and 34 cycles with an early GnRH antagonist start protocol. The second cohort (Cohort II) that underwent IVF between June 2012 and February 2013 included a total of 150 embryo-transfer (ET) cycles. Forty-three cycles were treated with the conventional GnRH antagonist protocol, 34 cycles with the modified early GnRH antagonist start protocol using highly purified human menopause gonadotropin and an addition of GnRH agonist to the luteal phase support, and 73 cycles with the GnRH agonist long protocol. Results: The analysis of Cohort I showed that the number of mature oocytes retrieved was significantly higher in the early GnRH antagonist start cycles than in the conventional antagonist cycles (11.9 vs. 8.2, p=0.04). The analysis of Cohort II revealed higher but non-significant CPR/ET in the modified early GnRH antagonist start cycles (41.2%) than in the conventional antagonist cycles (30.2%), which was comparable to that of the GnRH agonist long protocol cycles (39.7%). Conclusion: The modified early antagonist start protocol may improve the mature oocyte yield, possibly via enhanced follicular synchronization, while resulting in superior CPR as compared to the conventional antagonist protocol, which needs to be studied further in prospective randomized controlled trials.
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참고문헌 (26)
참고문헌 신청
Rabinovici J / 1992 / Endocrine effects and pharmacokinetic characteristics of a potent new gonadotropin-releasing hormone antagonist (Ganirelix)with minimal histamine-releasing properties: studies in postmenopausal women / J Clin Endocrinol Metab 75:1220~1225
Al-Inany H / 2005 / Optimizing GnRH antagonist administration: meta-analysis of fixed versus flexible protocol / Reprod Biomed Online 10:567~570
Kolibianakis EM / 2006 / Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis / Hum Reprod Update 12:651~671
Greco E / 2007 / GnRH antagonists in ovarian stimulation for ICSI with oocyte restriction:a matched, controlled study / Reprod Biomed Online 14:572~578
Depalo R / 2009 / Follicular growth and oocyte maturation in GnRH agonist and antagonist protocols for in vitro fertilisation and embryo transfer / Gynecol Endocrinol 25:328~334
Al-Inany H / 2005 / Optimizing GnRH antagonist administration: meta-analysis of fixed versus flexible protocol / Reprod Biomed Online 10:567~570
Kolibianakis EM / 2006 / Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis / Hum Reprod Update 12:651~671
Greco E / 2007 / GnRH antagonists in ovarian stimulation for ICSI with oocyte restriction:a matched, controlled study / Reprod Biomed Online 14:572~578
Depalo R / 2009 / Follicular growth and oocyte maturation in GnRH agonist and antagonist protocols for in vitro fertilisation and embryo transfer / Gynecol Endocrinol 25:328~334
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