Significance of the serum CA-125 level in intrauterine insemination cycles

Choe, Seung-Ah; Ku, Seung-Yup; Jee, Byung-Chul; Suh, Chang-Suk; Kim, Seok-Hyun; Choi, Young-Min; Kim, Jung-Gu; Moon, Shin-Young

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자료유형: 학술저널

저자정보: Choe, Seung-Ah (Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National Univer) Ku, Seung-Yup (Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National Univers) Jee, Byung-Chul (Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National Unive) Suh, Chang-Suk (Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National Univer) Kim, Seok-Hyun (Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Institute of Reproductive Medicine and Population, Medical Resea) Choi, Young-Min Kim, Jung-Gu Moon, Shin-Young

저널정보: 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제38권 제3호

발행연도: 2011.1

수록면: 164 - 167 (4page)

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Objective: There are limited data regarding the significance of elevated serum CA-125 level during IUI cycles, even though it is used widely during the initial evaluation of infertile patients. The aim of this study was to investigate the prognostic value of serum CA-125 levels during IUI cycles. Methods: Among the patients with controlled ovarian stimulation and IUI cycles at Seoul National University Hospital from Jan 2005 through Dec 2009, 92 cases with no identified endometriotic lesion, ovarian tumor, salpingeal lesion, or uterine myoma were selected. To compare the clinical characteristics between the pregnancy group and the non-pregnancy group, the Mann-Whitney U test and Fisher's exact test were used. Results: The overall pregnancy rate was 18.5% (17/92). The pregnancy group showed a higher number of follicles 16 mm in diameter ($p$=0.036), endometrial thickness ($p$ <0.001), ampules of gonadotropin ($p$=0.009), and higher body mass index ($p$=0.022) than the non-pregnancy group. No significant difference was observed in the serum CA-125 level or the proportion of patients with CA-125 exceeding 17 IU/mL between the two groups. Conclusion: The prognostic value of serum CA-125 level among infertile patients with IUI cycles is considered limited.

#CA-125 Antigen #Intrauterine Insemination #Human

참고문헌 (25)

참고문헌 신청

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Nuojua-Huttunen S / 1999 / Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome / Hum Reprod 14:698~703

Colacurci N / 1996 / Serum and peritoneal CA-125 levels as diagnostic test for endometriosis / Eur J Obstet Gynecol Reprod Biol 66:41~43

Medeiros LR / 2009 / Accuracy of CA 125 in the diagnosis of ovarian tumors: a quantitative systematic review / Eur J Obstet Gynecol Reprod Biol 142:99~105