지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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The biological effects of radiation are dependent on the dose rate and dose of radiation. In this study, effects of dose and dose rate using whole body radiation on plasma cytokines and blood count from male BALB/c mice were evaluated. We examined the blood and cytokine changes in mice exposed to a low (3.49m Gy $h^{-1}$) and high (2.6 Gy $min^{-1}$) dose rate of radiation at a total dose of 0.5 and 2 Gy, respectively. Blood from mice exposed to radiation were evaluated using cytokine assays and complete blood count. Peripheral lymphocytes and neutrophils decreased in a dose dependent manner following high dose rate radiation. The peripheral lymphocytes population remained unchanged following low dose rate radiation; however, the neutrophils population increased after radiation. The sera from these mice exhibited elevated levels of flt3 ligand and granulocyte-colony-stimulating factor (G-CSF), after high/low dose rate radiation. These results suggest that low-dose-rate radiation does not induce blood damage, which was unlike high-dose-rate radiation treatment; low-dose-rate radiation exposure activated the hematopoiesis through the increase of flt3 ligand and G-CSF.
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참고문헌 (20)
참고문헌 신청
Brenner DJ / 2003 / Cancer risks attributable to low doses of ionizing radiation: assessing what we really know / Proc. Natl. Acad. Sci. USA 100:13761~13766
Pandey R / 2005 / Low dose radiation induced immunomodulation: effect on macrophages and CD8+ T cells / Int. J. Radiat. Bio 81:801~812
Ren H / 2006 / Augmentation of innate immunity by low-dose irradiation / Cell Immunol 244:50~56
김성대 / 2012 / 저선량율 방사선 조사한 BALB/c 마우스에서의 영향평가 / 방사선방어학회지 37(3):159~165
Lee DK / 2002 / Effects on heamopoietic cells and chromosomal DNA of leukocytes in mice irradiated with low dose of X-ray I. Changes of leukocyte, lymphocyte, thrombocyte and erythrocyte number / Kor. J. Vet. Phbl 26:143~152
Pandey R / 2005 / Low dose radiation induced immunomodulation: effect on macrophages and CD8+ T cells / Int. J. Radiat. Bio 81:801~812
Ren H / 2006 / Augmentation of innate immunity by low-dose irradiation / Cell Immunol 244:50~56
김성대 / 2012 / 저선량율 방사선 조사한 BALB/c 마우스에서의 영향평가 / 방사선방어학회지 37(3):159~165
Lee DK / 2002 / Effects on heamopoietic cells and chromosomal DNA of leukocytes in mice irradiated with low dose of X-ray I. Changes of leukocyte, lymphocyte, thrombocyte and erythrocyte number / Kor. J. Vet. Phbl 26:143~152
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