지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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While high-dose ionizing radiation results in long term cellular cytotoxicity, chronic low-dose (<0.2 Gy) of X- or ${\gamma}$-ray irradiation can be beneficial to living organisms by inducing radiation hormesis, stimulating immune function, and adaptive responses. During chronic low-dose-rate radiation (LDR) exposure, whole body of mice is exposed to radiation, however, it remains unclear if LDR causes changes in gene expression of the whole brain. Therefore, we aim to investigate expressed genes (EGs) and signaling pathways specifically regulated by LDR-irradiation ($^{137}Cs$, a cumulative dose of 1.7 Gy for total 100 days) in the whole brain. Using microarray analysis of whole brain RNA extracts harvested from ICR and AKR/J mice after LDR-irradiation, we discovered that two mice strains displayed distinct gene regulation patterns upon LDR-irradiation. In ICR mice, genes involved in ion transport, transition metal ion transport, and developmental cell growth were turned on while, in AKR/J mice, genes involved in sensory perception, cognition, olfactory transduction, G-protein coupled receptor pathways, inflammatory response, proteolysis, and base excision repair were found to be affected by LDR. We validated LDR-sensitive EGs by qPCR and confirmed specific upregulation of S100a7a, Olfr624, and Gm4868 genes in AKR/J mice whole brain. Therefore, our data provide the first report of genetic changes regulated by LDR in the mouse whole brain, which may affect several aspects of brain function.
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참고문헌 (24)
참고문헌 신청
Otake M / 1998 / Radiation-related brain damage and growth retardation among the prenatally exposed atomic bomb survivors. Int / J. Radiat. Biol 74(2):159~171
Schull WJ / 1999 / Cognitive function and prenatal exposure to ionizing radiation / Teratology 59(4):222~226
Bálentová S / 2006 / Cell proliferation in the adult rat rostral migratory stream following exposure to gamma irradiation / Cell Mol. Neurobiol 26(7-8):1131~1139
Lee WH / 2011 / Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain / Radiat. Res 176(6):753~760
Lee WH / 2010 / Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain / Neurosci. Lett 476(2):89~93
Schull WJ / 1999 / Cognitive function and prenatal exposure to ionizing radiation / Teratology 59(4):222~226
Bálentová S / 2006 / Cell proliferation in the adult rat rostral migratory stream following exposure to gamma irradiation / Cell Mol. Neurobiol 26(7-8):1131~1139
Lee WH / 2011 / Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain / Radiat. Res 176(6):753~760
Lee WH / 2010 / Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain / Neurosci. Lett 476(2):89~93
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