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논문 기본 정보

자료유형
학술저널
저자정보
Song, Hee-Sung (Department of Nuclear Medicine, Ajou University School of Medicine) Lee, Su-Jin (Department of Nuclear Medicine, Ajou University School of Medicine) Yoon, Seok-Ho (Department of Nuclear Medicine, Ajou University School of Medicine) Lee, Jan-Dee (Department of Surgery, Ajou University School of Medicine) Soh, Euy-Young (Department of Surgery, Ajou University School of Medicine) An, Young-Sil (Department of Nuclear Medicine, Ajou University School of Medicine) Yoon, Joon-Kee (Department of Nuclear Medicine, Ajou University School of Medicine)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제45권 제3호
발행연도
2011.1
수록면
197 - 202 (6page)

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Purpose We investigated the clinical significance of diffuse uptake in remaining thyroid after unilateral lobectomy for thyroid cancer. Methods A total of 144 thyroid cancer patients who underwent $^{18}F$-FDG PET/CT after lobectomy were enrolled in the present study. The PET/CT images were evaluated for the presence of diffuse $^{18}F$-FDG uptake with maximum SUV (SUVmax) >2.0 in the residual thyroid and placed into one of two groups: with diffuse uptake and without diffuse uptake group. Clinical, laboratory, and PET/CT parameters in both groups were compared. Correlations between SUVmax of thyroid and available parameters were analyzed. Results Forty-two of 144 patients (29.2%) had diffuse thyroid uptake (mean SUVmax: $3.2{\pm}1.1$). All patients with diffuse uptake and 96 (94.1%) without diffuse uptake were receiving thyroxine therapy (P=0.09). Thyroid function tests showed that most patients were euthyroid status (78.6 vs. 85.3%, P=0.36). TgAb levels were significantly higher in patients with diffuse uptake ($338.0{\pm}664.6$ vs. $57.3{\pm}46.4$, P<0.0001). Mean attenuation values in the diffuse uptake group were significantly lower ($72.2{\pm}15$. vs. $97.0{\pm}16.0$, P<0.0001). An inverse correlation was found between SUVmax and mean attenuation values of residual thyroid in all patients (r=-0.57, P<0.0001) and subgroup with diffuse uptake (r=-0.31, P<0.05). Conclusion In this study, diffuse $^{18}F$-FDG uptake in the residual thyroid after unilateral lobectomy was a relatively frequent finding and may be associated with chronic thyroiditis. This uptake is not influenced by thyroid status or thyroxine therapy. The $^{18}F$-FDG uptake is inversely correlated with mean attenuation value of thyroid.

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