지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 431 - 437 (7page)
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초록· 키워드
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Calpains are a class of proteins that belong to the calcium-dependent, non-lysosomal cysteine proteases. There are three major types of calpains expressed in the skeletal muscle, namely, ${\mu}$-calpain, m-calpain, and calpain 3, which show proteolytic activities. Skeletal muscle fibers possess all three calpains, and they are $Ca^{2+}$-dependent proteases. The functional role of calpains was found to be associated with apoptosis and myogenesis. However, calpain 3 is likely to be involved in sarcomeric remodeling. A defect in the expression of calpain 3 leads to limb-girdle muscular dystrophy type 2A. Calpain 3 is found in skeletal muscle fibers at the N2A line of the large elastic protein, titin. A substantial proportion of calpain 3 is activated 24 h following a single bout of eccentric exercise. In vitro studies indicated that calpain 3 can be activated 2-4 fold higher than normal resting cytoplasmic [$Ca^{2+}$]. Characterization of the calpain system in the developing muscle is essential to explain which calpain isoforms are present and whether both ${\mu}$-calpain and m-calpain exist in differentiating myoblasts. Information from such studies is needed to clarify the role of the calpain system in skeletal muscle growth. It has been demonstrated that the activation of ubiquitous calpains and calpain 3 in skeletal muscle is very well regulated in the presence of huge and rapid changes in intracellular [$Ca^{2+}$].
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참고문헌 (48)
참고문헌 신청
Baghdiguian S / 2001 / Pathophysiology of limb girdle muscular dystrophy type 2A : hypothesis and new insights into the IkBa/NF-kB survival pathway in skeletal muscle / J Mol Med 79:254~261
Barnoy S / 1996 / The role of calpastatin(the specific inhibitor)in myoblast differentiation and fusion / Biochim Biophys Res Commun 220:933~938
Barnoy S / 1997 / Calpain and calpastatin in myoblast differentiation and fusion effects of inhibitors / Biochim Biophys Acta 1358:181~188
Beckmann JS / 2008 / Calpain 3, the ‘‘gatekeeper’’ of proper sarcomere assembly, turnover and maintenance / Neuromusc Disord 18:913~921
Boehm ML / 1998 / Changes in the calpains and calpastatin during postmortem storage of bovine muscle / J Anim Sci 76:2415~2434
Barnoy S / 1996 / The role of calpastatin(the specific inhibitor)in myoblast differentiation and fusion / Biochim Biophys Res Commun 220:933~938
Barnoy S / 1997 / Calpain and calpastatin in myoblast differentiation and fusion effects of inhibitors / Biochim Biophys Acta 1358:181~188
Beckmann JS / 2008 / Calpain 3, the ‘‘gatekeeper’’ of proper sarcomere assembly, turnover and maintenance / Neuromusc Disord 18:913~921
Boehm ML / 1998 / Changes in the calpains and calpastatin during postmortem storage of bovine muscle / J Anim Sci 76:2415~2434
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