Callophyllis japonica extract improves high-fat diet-induced obesity and inhibits adipogenesis in 3T3-L1 cells

Kang, Seong-Il; Shin, Hye-Sun; Kim, Hyo-Min; Yoon, Seon-A; Kang, Seung-Woo; Ko, Hee-Chul; Kim, Se-Jae

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자료유형: 학술저널

저자정보: Kang, Seong-Il (Department of Biology, Jeju National University) Shin, Hye-Sun (Department of Biology, Jeju National University) Kim, Hyo-Min (Department of Biology, Jeju National University) Yoon, Seon-A (Department of Biology, Jeju National University) Kang, Seung-Woo (Department of Biology, Jeju National University) Ko, Hee-Chul (Department of Biology, Jeju National University) Kim, Se-Jae (Department of Biology, Jeju National University)

저널정보: 한국통합생물학회 Animal cells and systems Animal cells and systems 제16권 제6호

발행연도: 2012.1

수록면: 447 - 454 (8page)

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The anti-obesity potential of an ethanolic extract of the edible red alga Callophyllis japonica extract (CJE) was investigated in mice fed a high-fat diet (HFD). CJE administration into HFD mice revealed suppression of body weight, adipose tissue weight, serum total cholesterol, triglyceride, and glucose levels in a dose-dependent manner. Also, it reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase, as well as the accumulation of fatty droplets in liver tissue. CJE and its ethyl acetate fraction inhibited adipogenesis in 3T3-L1 adipocytes by down-regulating the adipocyte-specific transcriptional regulators. Taken together, these results suggest that CJE reduces obesity in mice fed an HFD by inhibiting lipid accumulation and adipogenesis in the adipose tissues.

#Callophyllis japonica #high-fat diet-induced obesity #anti-obesity #3T3-L1 cells

참고문헌 (27)

참고문헌 신청

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