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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 115 - 121 (7page)
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초록· 키워드
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Previous studies have demonstrated that N-methyl-D-aspartate (NMDA) receptors and acetylcholine receptors are related to learning and memory in rat and mice. In this study, we examined the effects of MK-801, a non-competitive NMDA receptor antagonist, on learning and memory in zebrafish using a passive avoidance test. We further tested whether or not nicotine, a nicotinic acetylcholine receptor agonist, and physostigmine, an acetylcholinesterase inhibitor, reverse the effects of MK-801. Crossing time was increased significantly in the training and test sessions for the controls. When 20 ${\mu}M$ MK-801 was administered prior to the training session, the crossing time did not increase in either session. The MK-801-induced learning deficit was rescued by pretreatment with 20 ${\mu}M$ physostigmine, and crossing time was increased in the training and test sessions compared to the MK-801-treated zebrafish. Further, the MK-801-induced learning deficit was prevented by pretreatment with 20 ${\mu}M$ nicotine, and crossing time was increased in the training session but not in the test session. These results show that MK-801 induced a learning deficit in zebrafish that was prevented by pretreatment with nicotine and physostigmine.
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참고문헌 (31)
참고문헌 신청
Blank M / 2009 / A one-trial inhibitory avoidance task to zebrafish: rapid acquisition of an NMDA-dependent long-term memory / Neurobiol Learn Mem 92:529~534
Boccia MM / 2003 / Atropine, an anticholinergic drug, impairs memory retrieval of a high consolidated avoidance response in mice / Neurosci Lett 345:97~100
Csernansky JG / 2005 / Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice / Neuropsychopharmacology 30:2135~2143
De-Mello N / 2002 / Elevated T-maze as an animal model of memory: effects of scopolamine / Behav Pharmacol 13:139~148
Dong H / 2005 / Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer’s disease / Psychopharmacology (Berl) 181:145~152
Boccia MM / 2003 / Atropine, an anticholinergic drug, impairs memory retrieval of a high consolidated avoidance response in mice / Neurosci Lett 345:97~100
Csernansky JG / 2005 / Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice / Neuropsychopharmacology 30:2135~2143
De-Mello N / 2002 / Elevated T-maze as an animal model of memory: effects of scopolamine / Behav Pharmacol 13:139~148
Dong H / 2005 / Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer’s disease / Psychopharmacology (Berl) 181:145~152
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