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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Dae-Weung (Department of Nuclear Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine) Kim, Woo Hyoung (Department of Nuclear Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine) Kim, Chang Guhn (Department of Nuclear Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제46권 제3호
발행연도
2012.1
수록면
196 - 200 (5page)

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Purpose Dual-time-point (DTP) FDG PET/CT has been shown to be useful for lymph node (LN) staging in patients with non-small-cell lung cancer (NSCLC). The aim of this study was to evaluate the LN staging ability of DTP FDG PET/CT in the predominant area of pulmonary tuberculosis. Methods Sixty-nine NSCLC patients underwent DTP PET/CT. Regions of interest were placed on each LN of each station, and the maximum SUVs were measured. Three variables were obtained: (1) the SUV on the early scan ($SUV_{early}$), (2) the SUV on the delayed scan ($SUV_{delayed}$), and (3) the retention index of the SUV (RI). Each patient had one final LN stage and three other LN stages according to the cutoff values of $SUV_{early}$, $SUV_{delayed}$, and RI. Results In the LN-based analysis, the area under the ROC curve of $SUV_{delayed}$ (0.884) was significantly larger (P< 0.01) than those of $SUV_{early}$ (0.868) and RI (0.717). Among the three variables, $SUV_{delayed}$ was more accurate (P<0.01) for detecting the mediastinal LN metastasis than $SUV_{early}$ and RI. In the patient-based analysis, $SUV_{delayed}$ had correctly determined LN stages in 55 of 69 patients (sensitivity, specificity, and accuracy=88.7 %, 50.0 %, and 79.7 %), whereas $SUV_{early}$ and RI correctly determined LN stages in 53 and 52 patients, respectively. Conclusions In this study, comparing the diagnostic efficacy of $SUV_{early}$, $SUV_{delayed}$, and RI for LN staging in patients with NSCLC, $SUV_{delayed}$ was the most accurate variable for LN staging. DTP PET/CT could provide improved diagnostic accuracy for the LN staging of NSCLC.
#Non-small-cell lung cancer #Fluorodeoxyglucose #Positron emission tomography #Dual-time-point imaging #Lymph node staging

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참고문헌 (16)

참고문헌 신청
Mountain CF / 1997 / Revisions in the International System for Staging Lung Cancer / Chest 111:1710~1717 google schola Gupta NC / 2001 / Mediastinal lymph node sampling following positron emission tomography with fluorodeoxyglucose imaging in lung cancer staging / Chest 120:521~527 google schola Konishi J / 2003 / Mediastinal lymph node staging by FDG-PET in patients with non-small cell lung cancer: analysis of false-positive FDG-PET findings / Respiration 70:500~506 google schola Takamochi K / 2005 / Pitfalls in lymph node staging with positron emission tomography in non-small cell lung cancer patients / Lung Cancer 47:235~244 google schola Kubota R / 1994 / Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake / J Nucl Med 35:104~112 google schola

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