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논문 기본 정보

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학술저널
저자정보
Park, Soo-Bin (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Choi, Joon-Young (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lee, Eun-Jeong (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Yoo, Jang (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Cheon, Mi-Ju (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Cho, Suk-Kyong (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Choe, Yearn-Seong (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lee, Kyung-Han (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) Kim, Byung-Tae (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제46권 제2호
발행연도
2012.1
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95 - 101 (7page)

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Purpose : We investigated PET/CT diagnostic criteria for differentiating benign from malignant parotid lesions with focal $^{18}F$-FDG uptake. Methods : The subjects of the study were 272 patients who exhibited focal $^{18}F$-FDG uptake of the parotid gland. Sixty-eight pathologically confirmed parotid lesions from 67 patients were included. The maximum SUV (SUVmax), uptake patterns (homogeneous vs. heterogeneous), size measured by CT, maximum Hounsfield units (HUmax) and margins on CT (well vs. ill defined) of each parotid lesion on PET/CT images were compared with final diagnoses. Results : Thirty-two parotid lesions were histologically proven to be malignant. There were significant differences in uptake patterns (cancer incidence, heterogeneous:homogeneous=79.2%:29.5%, p<0.0001) and margins on CT (cancer incidence, ill:well defined084.4%:13.3%, p<0.0001) between benign and malignant lesions. The cancer risks of parotid lesions were 89.5% with heterogeneous uptake and ill-defined margins, 70.6% with heterogeneous uptake or ill-defined margins (no overlap in subjects) and 9.3% with homogeneous uptake and well-defined margins (p<0.0001). When any lesion with heterogeneous uptake or ill-defined margins was regarded as malignant, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 90.6% (29/32), 80.6% (29/36), 80.6% (29/36), 90.6%(29/32) and 85.6%(58/68), respectively. For predicting malignancy, combined PET/CT criteria showed better sensitivity, NPV and accuracy than PET-only criteria, and had a tendency to have more accurate results than CT-only criteria. There were no significant differences in SUVmax, size or HUmax between benign and malignant lesions. Conclusion : Uptake patterns and margins on CT are useful PET/CT diagnostic criteria for differentiating benign from malignant lesions.
#F-FDG #PET #PET/CT #Parotid gland #Cancer

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