지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제46권 제3호
- 발행연도
- 2012.1
- 수록면
- 162 - 168 (7page)
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초록· 키워드
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Purpose Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) is a well-known serious complication of BP treatment. This study was undertaken to evaluate the diagnostic usefulness of three-phase bone scintigraphy in patients with BRONJ. Methods Forty-one patients (48 lesions) with clinically proven BRONJ (2 males, 39 females, age $74.3{\pm}6.7$ years) underwent Tc-99 m HDP bone scintigraphy. Visual interpretation and semiquantitative analysis of uptakes using lesion-to-contralateral uptake ratios during the blood pool phase (BUR) and during the osseous phase (OUR) were performed, and relations were sought between these and various clinical parameters. Results Three-phase bone scintigraphy showed increased perfusion and blood pooling in 21 (63.6 %) and 27 (81.8 %) of 33 lesions, respectively. The osseous phase was positive for 45 (93.8 %) of the 48 lesions. Of the four inflammatory clinical parameters of BRONJ [pus discharge, pain, swelling, and erythrocyte sedimentation rate (ESR)], patients with three or more parameters had more positive findings in vascular and blood pool phase images (p=0.033, p=0.027). By semiquantitative analysis, patients with a positive ESR had statistically higher BUR and OUR (both p<0.001). Higher stage BRONJ lesions had higher OUR than lower stage lesions (p=0.003). In addition, bone scintigraphy revealed three clinically covert BRONJ lesions without bone exposure, and four patients were up-staged based on bone scintigraphy. Conclusions Bone scintigraphy provides a relatively sensitive means of detecting BRONJ, so it was helpful for accurate BRONJ staging. Furthermore, increased uptakes in vascular and blood pool phases of three-phase bone scintigraphy were related to the inflammatory activity of BRONJ.
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참고문헌 (18)
참고문헌 신청
Yoneda T / 2010 / Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons / J Bone Miner Metab 28:365~383
Migliorati CA / 2006 / Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment / Lancet Oncol 7:508~514
Allen MR / 2009 / The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data / J Oral Maxillofac Surg 67:61~70
Ruggiero SL / 2011 / Bisphosphonate-related osteonecrosis of the jaw: an overview / Ann N Y Acad Sci 1218:38~46
Ruggiero SL / 2009 / American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw—2009 update / J Oral Maxillofac Surg 67:2~12
Migliorati CA / 2006 / Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment / Lancet Oncol 7:508~514
Allen MR / 2009 / The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data / J Oral Maxillofac Surg 67:61~70
Ruggiero SL / 2011 / Bisphosphonate-related osteonecrosis of the jaw: an overview / Ann N Y Acad Sci 1218:38~46
Ruggiero SL / 2009 / American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw—2009 update / J Oral Maxillofac Surg 67:2~12
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