지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제46권 제4호
- 발행연도
- 2012.1
- 수록면
- 254 - 260 (7page)
이용수
초록· 키워드
오류제보하기
Purpose $^{18}F$-FP-CIT positron emission tomography (PET) is an effective imaging for dopamine transporters. In usual clinical practice, $^{18}F$-FP-CIT PET is analyzed visually or quantified using manual delineation of a volume of interest (VOI) for the striatum. In this study, we suggested and validated two simple quantitative methods based on automatic VOI delineation using statistical probabilistic anatomical mapping (SPAM) and isocontour margin setting. Methods Seventy-five $^{18}F$-FP-CIT PET images acquired in routine clinical practice were used for this study. A study-specific image template was made and the subject images were normalized to the template. Afterwards, uptakes in the striatal regions and cerebellum were quantified using probabilistic VOI based on SPAM. A quantitative parameter, $Q_{SPAM}$, was calculated to simulate binding potential. Additionally, the functional volume of each striatal region and its uptake were measured in automatically delineated VOI using isocontour margin setting. Uptake-volume product ($Q_{UVP}$) was calculated for each striatal region. $Q_{SPAM}$ and $Q_{UVP}$ were compared with visual grading and the influence of cerebral atrophy on the measurements was tested. Results Image analyses were successful in all the cases. Both the $Q_{SPAM}$ and $Q_{UVP}$ were significantly different according to visual grading (P<0.001). The agreements of $Q_{UVP}$ or $Q_{SPAM}$ with visual grading were slight to fair for the caudate nucleus (${\kappa}$=0.421 and 0.291, respectively) and good to perfect to the putamen (${\kappa}$=0.663 and 0.607, respectively). Also, $Q_{SPAM}$ and $Q_{UVP}$ had a significant correlation with each other (P<0.001). Cerebral atrophy made a significant difference in $Q_{SPAM}$ and $Q_{UVP}$ of the caudate nuclei regions with decreased $^{18}F$-FP-CIT uptake. Conclusion Simple quantitative measurements of $Q_{SPAM}$ and $Q_{UVP}$ showed acceptable agreement with visual grading. Although $Q_{SPAM}$ in some group may be influenced by cerebral atrophy, these simple methods are expected to be effective in the quantitative analysis of $^{18}F$-FP-CIT PET in usual clinical practice.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Niznik HB / 1991 / The dopamine transporter is absent in parkinsonian putamen and reduced in the caudate nucleus / J Neurochem 56:192~198
Klaffke S / 2006 / Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration / Mov Disord 21:1724~1727
Kas A / 2007 / Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images / J Nucl Med 48:1459~1467
오소원 / 2009 / 123I-FP-CIT SPECT를 이용한 다중계위축증 및 조기 파킨슨병에서의 평가 / Nuclear Medicine and Molecular Imaging 43(1):10~18
Kazumata K / 1998 / Dopamine transporter imaging with fluorine- 18-FPCIT and PET / J Nucl Med 39:1521~1530
Klaffke S / 2006 / Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration / Mov Disord 21:1724~1727
Kas A / 2007 / Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images / J Nucl Med 48:1459~1467
오소원 / 2009 / 123I-FP-CIT SPECT를 이용한 다중계위축증 및 조기 파킨슨병에서의 평가 / Nuclear Medicine and Molecular Imaging 43(1):10~18
Kazumata K / 1998 / Dopamine transporter imaging with fluorine- 18-FPCIT and PET / J Nucl Med 39:1521~1530
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