지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제45권 제2호
- 발행연도
- 2011.1
- 수록면
- 125 - 131 (7page)
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초록· 키워드
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Purpose Pheochromocytoma (PH) is a rare catecholaminesecreting tumor that arises from chromaffin tissue within the adrenal medulla and extra-adrenal sites; commonly it is sporadic, and malignant PH accounts for about 10% of all cases. Several imaging modalities have been used for the diagnosis and staging of this tumor: functional imaging using radio-labelled metaiodobenzylguanidine and, more recently, $^{18}F$-fluorodeoxyglucose positron emission tomography ($^{18}F$-FDG PET/CT), which offers substantial sensitivity and specificity to correctly detect metastatic PH and helps to identify patients suitable for treatment with radiopharmaceuticals. The aim of our study was to compare CT, $^{18}F$-FDG PET/CT, and $^{123}I$-metaiodobenzylguanidine single photon emission tomography ($^{123}I$-MIBG SPECT) as feasible methods to restage patients diagnosed histologically with PH. Methods We retrospectively evaluated 38 patients (27 females and 11 males; mean age: $44{\pm}15$ years) with malignant PH documented histologically after surgical intervention. These patients underwent CT, $^{18}F$-FDG PET/CT, and $^{123}I$-MIBG SPECT. Results $^{18}F$-FDG PET/CT showed positive results for neoplastic tissue in 33/38 patients (86.8%) and negative in 5/38 (13.2%), in concordance with CT alone. $^{123}I$-MIBG SPECT was positive in 30/38 patients (78,9%) and negative in 8/38 (21.1%). No differences in lesion numbers were found between $^{18}F$-FDG PET/CT and CT, whereas a difference could be demonstrated between $^{18}F$-FDG PET/CT and $^{123}I$-MIBG SPECT. Conclusion $^{18}F$-FDG PET/CT could more accurately restage patients with PH than CT and $^{123}I$-MIBG SPECT, also in the absence of a staging study.
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