지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제45권 제2호
- 발행연도
- 2011.1
- 수록면
- 87 - 92 (6page)
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초록· 키워드
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Background $^{66}Ho$-chloride was obtained by bombardment of natural $Ho(NO_3){_3}$ dissolved in acidic media using thermal neutron flux ($4-5{\times}10^{13}n.cm^{-2}.s^{-1}$). Methods $^{166}Ho$-holmium chloride (185 MBq) was used successfully for preparation of $^{166}Ho$-phytate complex with high radiochemical purity (>99.9 %, ITLC, MeOH: $H_2O$: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to 2 days. The prepared complex solution ($60{\mu}Ci/100{\mu}l$) was injected intraarticularly to male rat knee joints. Leakage of radioactivity from the injection site and its distribution in organs were investigated up to 2 days. Results Approximately all of the injected dose had remained in the injection site 2 days after injection. Conclusion The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology.
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