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논문 기본 정보

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학술저널
저자정보
Kim, Chul-Han (Department of Nuclear Medicine, Hospital, National Cancer Center) Kim, In-Hye (Molecular Imaging and Therapy Branch, Research Institute, National Cancer Center) Kim, Seo-Il (Molecular Imaging and Therapy Branch, Research Institute, National Cancer Center) Kim, Young-Sang (Molecular Imaging and Therapy Branch, Research Institute, National Cancer Center) Kang, Se-Hun (Molecular Imaging and Therapy Branch, Research Institute, National Cancer Center) Moon, Seung-Hwan (Department of Nuclear Medicine, Hospital, National Cancer Center) Kim, Tae-Sung (Department of Nuclear Medicine, Hospital, National Cancer Center) Kim, Seok-Ki (Department of Nuclear Medicine, Hospital, National Cancer Center)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제45권 제3호
발행연도
2011.1
수록면
169 - 176 (8page)

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Purpose We compared alternative routes for $^{18}F$-fluorodeoxyglucose (FDG) administration, such as the retroorbital (RO), intraperitoneal (IP) and per oral (PO) routes, with the intravenous (IV) route in normal tissues and tumors of mice. Materials and Methods CRL-1642 (ATCC, Lewis lung carcinoma) cells were inoculated in female BALB/c-nu/nu mice 6 to 10 weeks old. When the tumor grew to about 9 mm in diameter, positron emission tomography (PET) scans were performed after FDG administration via the RO, IP, PO or IV route. Additional serial PET scans were performed using the RO, IV or IP route alternatively from 5 to 29 days after the tumor cell injection. Results There was no significant difference in the FDG uptake in normal tissues at 60 min after FDG administration via RO, IP and IV routes. PO administration, however, showed delayed distribution and unwanted high gastrointestinal uptake. Tumoral uptake of FDG showed a similar temporal pattern and increased until 60 min after FDG administration in the RO, IP and IV injection groups. In the PO administration group, tumoral uptake was delayed and reduced. There was no statistical difference among the RO, IP and IVadministration groups for additional serial PET scans. Conclusion RO administration is an effective alternative route to IV administration for mouse FDG PET scans using normal mice and tumor models. In addition, IP administration can be a practical alternative in the late phase, although the initial uptake is lower than those in the IV and RO groups.
#Administration route #Intraperitoneal #Retroorbital #Per oral #Intravenous #Small animal PET #FDG

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참고문헌 (13)

참고문헌 신청
Endepols H / 2010 / Effort-based decision making in the rat: an [18 F] fluorodeoxyglucose micro positron emission tomography study / J Neurosci 30:9708~9714 google schola Zhongxing Liang / 2011 / Potential Biomarker of L-type Amino Acid Transporter 1 in Breast Cancer Progression / Nuclear Medicine and Molecular Imaging 45(2):93~102 google schola Lancelot S / 2010 / Small-animal positron emission tomography as a tool for neuropharmacology / Trends Pharmacol Sci 31:411~417 google schola Frangioni JV / 2004 / In vivo tracking of stem cells for clinical trials in cardiovascular disease / Circulation 110:3378~3383 google schola Wyss MT / 2006 / Nano-PET imaging of [18F] fluoromisonidazole uptake in experimental mouse tumours / Eur J NuclMedMol Imaging 33:311~318 google schola

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