지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 188 - 193 (6page)
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초록· 키워드
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Objective : Moyamoya disease (MMD) is a chronic cerebrovascular occlusive disease of unknown etiology. In addition, the neurocognitive impairment of adults with MMD is infrequently reported and, to date, has not been well described. We attempted to determine both the neurocognitive profile of adult moyamoya disease and whether a superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis can improve the neurocognitive impairment in exhibiting hemodynamic disturbance without stroke. Methods : From September 2010 through November 2012, 12 patients with angiographically diagnosed MMD underwent STA-MCA anastomosis for hemodynamic impairment. Patients with hypoperfusion and impaired cerebrovascular reserve (CVR) capacity but without evidence of ischemic stroke underwent a cognitive function test, the Seoul Neuropsychological Screening Battery (SNSB). Five patients agreed to undergo a follow-up SNSB test. Data from preoperative and postoperative neurocognitive function tests were compared and analyzed. Results : Five of 12 patients were enrolled. The median age was 45 years (range, 24-55 years). A comparison of preoperative to postoperative status of SNSB, memory domain, especially delayed recall showed significant improvement. Although most of the domains showed improvement after surgery, the results were not statistically significant. Conclusion : In our preliminary study, large proportions of adult patients with MMD demonstrate disruption of cognitive function. This suggests the possibility of chronic hypoperfusion as a primary cause of the neurocognitive impairment. When preoperative and postoperative status of cognitive function was compared, memory domain showed remarkable improvement. Although further study is needed, neurocognitive impairment may be an indication for earlier intervention with reperfusion procedures that can improve cognitive function.
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참고문헌 (21)
참고문헌 신청
Calviere L / 2010 / Correlation between cognitive impairment and cerebral hemodynamic disturbances on perfusion magnetic resonance imaging in European adults with moyamoya disease. Clinical article / J Neurosurg 113:753~759
Chang KH / 1990 / MR imaging findings of moyamoya disease / J Korean Med Sci 5:85~90
Fujii K / 1997 / The efficacy of bypass surgery for the patients with hemorrhagic moyamoya disease / Clin Neurol Neurosurg 99(Suppl 2):S194~S195
Fukui M / 2000 / Moyamoya disease / Neuropathology 20(Suppl):S61~S64
Guzman R / 2009 / Clinical outcome after 450 revascularization procedures for moyamoya disease. Clinical article / J Neurosurg 111:927~935
Chang KH / 1990 / MR imaging findings of moyamoya disease / J Korean Med Sci 5:85~90
Fujii K / 1997 / The efficacy of bypass surgery for the patients with hemorrhagic moyamoya disease / Clin Neurol Neurosurg 99(Suppl 2):S194~S195
Fukui M / 2000 / Moyamoya disease / Neuropathology 20(Suppl):S61~S64
Guzman R / 2009 / Clinical outcome after 450 revascularization procedures for moyamoya disease. Clinical article / J Neurosurg 111:927~935
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