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논문 기본 정보

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학술저널
저자정보
Jee, Tae Keun (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) Jo, Kyung-Il (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) Seol, Ho Jun (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) Kong, Doo-Sik (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) Lee, Jung-Il (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) Shin, Hyung Jin (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제56권 제3호
발행연도
2014.1
수록면
194 - 199 (6page)

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Objective : Meningioma is the second most common primary central nervous system neoplasm. In contrast, chordoid meningioma is rare; due to the paucity of cases, little is known about its clinical features or treatment outcomes. The objectives of this study were to describe the clinical characteristics and outcomes for patients with chordoid meningioma. Methods : In total, 16 patients, with newly diagnosed chordoid meningioma who underwent surgical excision between 1999 and 2012 were included. We retrospectively evaluated the medical records, radiological findings, and pathological findings. The median follow-up period was 56.5 (range, 3-170) months. The MIB-1 labeling index ranged from 1 to 26.60% (median, 5.04). Results : Simpson grade I, II, and III resections were performed in four, nine, and three patients, respectively. The overall recurrence rate was 37.5%. Overall progression-free survival (PFS) after resection was 94.7 months (95% CI=62.9-126.6). Of the 4 patients with Simpson grade I resection, recurrence occurred in one patient. Among the Simpson grade II and III resection groups, eight patients underwent adjuvant radiation therapy and they showed significantly longer PFS (121 months, 95% CI=82.1-159.9) than the patients who underwent surgery alone (40.5 months, 95% CI=9.6-71.3) by the log-rank test (p<0.05). Conclusion : Chordoid meningiomas are difficult to manage and have a high rate of recurrence. Complete resection of the tumor is a key determinant of better outcomes. Adjuvant radiation therapy is recommended, eparticulary when Simpson grade I resection was not achieved.
#Chordoid meningioma #MIB-1 labeling index #Adjuvant radiation therapy

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참고문헌 (27)

참고문헌 신청
Amatya VJ / 2001 / Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21WAF1, and p27KIP1 expression in benign, atypical, and anaplastic meningiomas / Hum Pathol 32:970~975 google schola Barbaro NM / 1987 / Radiation therapy in the treatment of partially resected meningiomas / Neurosurgery 20:525~528 google schola Kyung Chul Choi / 2005 / Chordoid Meningioma / 대한신경외과학회지 38(5):390~392 google schola Goldsmith BJ / 1994 / Postoperative irradiation for subtotally resected meningiomas. A retrospective analysis of 140 patients treated from 1967 to 1990 / J Neurosurg 80:195~201 google schola Ho DM / 2002 / Histopathology and MIB-1 labeling index predicted recurrence of meningiomas : a proposal of diagnostic criteria for patients with atypical meningioma / Cancer 94:1538~1547 google schola

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