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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
You, Seung-Hoon (Department of Neurosurgery, Gangneung Asan Hospital, University of Ulsan College of Medicine) Jo, Sung-Min (Department of Neurosurgery, Gangneung Asan Hospital, University of Ulsan College of Medicine) Kim, Young-June (Department of Neurosurgery, Gangneung Asan Hospital, University of Ulsan College of Medicine) Lee, Jong-Hyeog (Department of Radiology, Gangneung Asan Hospital, University of Ulsan College of Medicine) Jo, Kwang-Deog (Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine) Park, Woong-Sub (Department of Preventive Medicine, College of Medicine, Gwandong University)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제54권 제4호
발행연도
2013.1
수록면
280 - 288 (9page)

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Objective : Perfusion computed tomography (PCT) has the ability to measure quantitative value and produce maps of mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV). We assessed cerebral hemodynamics by using these parameters and acetazolamide (ACZ) challenge for pre- and post-procedural evaluation in patients with unilateral cerebrovascular stenotic disease. Methods : Thirty patients underwent pre-procedural PCT with ACZ challenge, and 24 patients (80%) was conducted follow up PCT after angioplasty with same protocol. The mean MTT, CBF, and CBV were measured and compared in both middle cerebral arterial (MCA) territories before and after ACZ challenge. Hemispheric ratio and percent change after ACZ challenge were calculated before and after angioplasty. Results : The mean stenosis rate was 76.6%. Significant increases in MTT (32.6%, p=0.000) and significant decreases in CBF (-14.2%, p=0.000) were found in stenotic side MCA territories. After ACZ challenge, there were significant changes in MTT (37.4%, p=0.000), CBF (-13.1%, p=0.000), and CBV (-10.5%, p=0.001) in pre-procedural perfusion study. However, no significant increases were found in MTT, or decreases in CBF and CBV in post-procedural study. There were no significant changes after ACZ challenge also. In addition, the degrees of these changes (before and after ACZ challenge) were highly correlated with the stenotic degrees in pre-procedural perfusion study. Conclusion : PCT with ACZ challenge appears to be a useful tool to assess the cerebral perfusion status especially in patients with unilateral symptomatic stenotic disease.
#Intracranial stenotic disease #Cerebrovascular reserve #Perfusion CT #Acetazolamide challenge

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참고문헌 (26)

참고문헌 신청
Jung Yong Ahn / 2002 / Improved Cerebral Perfusion after Stent-Assisted Angioplasty for Middle Cerebral Artery Stenosis- Case Report - / 대한신경외과학회지 31(4):364~368 google schola Chen A / 2006 / Dynamic CT perfusion imaging with acetazolamide challenge for evaluation of patients with unilateral cerebrovascular steno-occlusive disease / AJNR Am J Neuroradiol 27:1876~1881 google schola Chimowitz MI / 2011 / Stenting versus aggressive medical therapy for intracranial arterial stenosis / N Engl J Med 365:993~1003 google schola Cianfoni A / 2007 / Brain perfusion CT : principles, technique and clinical applications / Radiol med 112:1225~1243 google schola Eastwood JD / 2002 / Dynamic CT perfusion imaging with acetazolamide challenge for the preprocedural evaluation of a patient with symptomatic middle cerebral artery occlusive disease / AJNR Am J Neuroradiol 23:285~287 google schola

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