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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Cho, Han-Jin (Department of Emergency Medicine, Korea University College of Medicine, Ansan Hospital) Sung, Yun-Hee (Department of Physical Therapy, Kyungnam University) Lee, Seung-Hwan (Department of Neurosurgery, Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong) Chung, Jun-Young (Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong) Kang, Jong-Man (Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong) Yi, Jae-Woo (Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제53권 제3호
발행연도
2013.1
수록면
139 - 144 (6page)

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Objective : Transient anterograde amnesia is occasionally observed in a number of conditions, including migraine, focal ischemia, venous flow abnormalities, and after general anesthesia. The inhalation anesthetic, isoflurane, is known to induce transient anterograde amnesia. We examined the involvement of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) in the underlying mechanisms of the isoflurane-induced transient anterograde amnesia. Methods : Adult male Sprague-Dawley rats were divided into three groups : the control group, the 10 minutes after recovery from isoflurane anesthesia group, and the 2 hours after recovery from isoflurane anesthesia group (n=8 in each group). The rats in the isoflurane-exposed groups were anesthetized with 1.2% isoflurane in 75% nitrous oxide and 25% oxygen for 2 hours in a Plexiglas anesthetizing chamber. Short-term memory was determined using the step-down avoidance task. BDNF and TrkB expressions in the hippocampus were evaluated by immunofluorescence staining and western blot analysis. Results : Latency in the step-down avoidance task was decreased 10 minutes after recovery from isoflurane anesthesia, whereas it recovered to the control level 2 hours after isoflurane anesthesia. The expressions of BDNF and TrkB in the hippocampus were decreased immediately after isoflurane anesthesia but were increased 2 hours after isoflurane anesthesia. Conclusion : In this study, isoflurane anesthesia induced transient anterograde amnesia, and the expressions of BDNF and TrkB in the hippocampus might be involved in the underlying mechanisms of this transient anterograde amnesia.
#Isoflurane #Anterograde amnesia #Brain-derived neurotrophic factor #Tyrosine kinase B receptor #Hippocampus

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참고문헌 (35)

참고문헌 신청
Alonso M / 2002 / BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation / Hippocampus 12:551~560 google schola Arancio O / 2007 / Neurotrophins, synaptic plasticity and dementia / Curr Opin Neurobiol 17:325~330 google schola Bartsch T / 2010 / Focal lesions of human hippocampal CA1 neurons in transient global amnesia impair place memory / Science 328:1412~1415 google schola Bliss TV / 1993 / A synaptic model of memory : long-term potentiation in the hippocampus / Nature 361:31~39 google schola Bortolon RJ / 2005 / Transient global amnesia after general anesthesia / Anesth Analg 101:916~919 google schola

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